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Prediabetes pp 119-125 | Cite as

The in Vivo Visualization of Insulitis a New Marker of Prediabetes

  • A. Signore
  • P. Pozzilli
  • G. Tamburrano
  • D. Andreani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

Type 1 (insulin-dependent) diabetes is a disease characterized by a prodromal period with beta-cell destruction mediated by mononuclear white blood cells and their products. Several markers have been identifyed to characterize the prodromal phase of the disease. During this phase alterations involving lymphocyte activation are present; an increased percentage of circulating activated lymphocytes is detectable and these cells show a decreased interlukin (IL2) production (1) together with an increased release of IL2 receptors (IL2R) which can be detected in serum (2).

Keywords

Prodromal Phase Gamma Camera Image Pancreatic Region Soluble IL2R Prodromal Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. Signore
    • 1
  • P. Pozzilli
    • 1
  • G. Tamburrano
    • 1
  • D. Andreani
    • 1
  1. 1.Endocrinologia (I), Clinica Medica (II), Policlinico Umberto IUniversita di Roma “La Sapienza”Italy

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