Prediabetes pp 101-107 | Cite as

Diabetic Lymphocytes Transfer and Beta Cell Functions

  • J. C. Basabe
  • L. E. Fabiano de Bruno
  • M. Arata
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


There is now consensus that the immune system is involved in the pathogenesis of insulin dependent diabetes mellitus (IDDM) in man and animals. This destructive autoimmune process may occur over a long-lasting period and only when a sufficient number of beta cells are destroyed does clinical evidence appear.


Beta Cell Beta Cell Function Beta Cell Mass Recipient Mouse Insulin Dependent Diabetes Mellitus Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eisenbarth, G.S.: Genes, generation of diversity, glycoconjugates and autoimmune beta cell insufficiency in Type I diabetes. Diabetes 1987; 36: 355–364.PubMedGoogle Scholar
  2. 2.
    Rossini, A.A., Mordes, J.P. and Like, A.A.: Immunology of insulin-de- pendent diabetes mellitus. Ann. Rev. Immunol. 1985; 3:289–320.CrossRefGoogle Scholar
  3. 3.
    Ganda, O., Srikanta, S., Brink, S., Morris, M.A., Gleason, R., Soeldner, C.S., and Eisenbarth, G.S.: Differential sensitivity to beta cell secretatogues in “early” type I diabetes mellitus. Diabetes 1984; 33:516–521.PubMedCrossRefGoogle Scholar
  4. 4.
    Buschard K., Masbad, S., and Rygaard, J.: Passive transfer of diabetes mellitus from man to mouse. Lancet 1978; 2:908–919.CrossRefGoogle Scholar
  5. 5.
    Rossini, A.A., Mordes, J.P., Williams, R., Pelletier, A., Like, A.: Failure to transfer insulitis to athymic recipients using BB/w rat lymphoid tissue transplant. Metabolism 1983 (32, suppl. 1); 80–96. (Sciences 1983; 220:727–733).PubMedCrossRefGoogle Scholar
  6. 6.
    Debray-Sachs, M., Sai, P., Boitard, C., Assan, R., and Hamburger, J.: Antipancreatic immunity in genetically diabetic mice. Clin. Exptl. Immunol. 1983; 51: 1–7.Google Scholar
  7. 7.
    Ono, J., Takabi, R., and Fukuma, M.: Preparation of single cells from pancreatic islets adult rat by the use of dispase. Endocrinol. Jpn. 1987; 24:265–270.CrossRefGoogle Scholar
  8. 8.
    Burr, I.M., Stauffacher, W., Balant, L., Renold, A., and Grodsky, G.: Regulation of insulin release in perifused pancreatic tissue. Acta Diabet. Lat. 1969; 6:580–596.Google Scholar
  9. 9.
    Herbert, V., Lau, K., Gottlieb, C., and Bleicher, S.J.: Coated charcoal immuno-assay of insulin. J. Clin. Endocrinol. Metab. 1965; 25:1375–1384.PubMedCrossRefGoogle Scholar
  10. 10.
    Kaldany, A., Hill, T., Wentworth, W., Brink, J.A., D’Elia, M., Clouse, M., and Soeldner, J.S.: Trapping of peripheral blood lymphocytes in the pancreas of oatients with acute-onset insulin-dependent diabetes mellitus. Diabetes 1982; 31:463–466.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. C. Basabe
    • 1
  • L. E. Fabiano de Bruno
    • 1
  • M. Arata
    • 1
  1. 1.Fundacion Laboratorio de Investigaciones Pediatricas (FLIP)Hospital General de Ninos “Dr. Pedro de Elizalde ”Buenos AiresArgentina

Personalised recommendations