Prediabetes pp 87-91 | Cite as

Studies of Prediabetes in the Spontaneously Diabetic BB Rat

  • Kenneth L. Brayman
  • James F. Markmann
  • Clyde F. Barker
  • Ali Naji
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


It is now well established that human type I diabetes is a chronic autoimmune process characterized by a rather “silent” prediabetic stage of several months to years in duration. (1) An important issue in diabetes research is the identification during the prediabetic period of subjects I at high risk of developing diabetes. Several immunologic and metabolic parameters have been studied to assess their reliability as predictors of 5 future development of diabetes in high risk individuals. Even if the combination of several of these factors proves to be highly specific in I defining the high risk individuals these studies require a lengthy follow-up period to ascertain their sensitivity and reliability in predicting impending diabetes.


Major Histocompatibility Complex Beta Cell Islet Allograft Autoimmune Beta Cell Prediabetic Stage 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kenneth L. Brayman
    • 1
  • James F. Markmann
    • 1
  • Clyde F. Barker
    • 1
  • Ali Naji
    • 1
  1. 1.Department of SurgeryUniversity of Pennsylvania, School of MedicinePhiladelphiaUSA

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