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Prediabetes pp 87-91 | Cite as

Studies of Prediabetes in the Spontaneously Diabetic BB Rat

  • Kenneth L. Brayman
  • James F. Markmann
  • Clyde F. Barker
  • Ali Naji
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

It is now well established that human type I diabetes is a chronic autoimmune process characterized by a rather “silent” prediabetic stage of several months to years in duration. (1) An important issue in diabetes research is the identification during the prediabetic period of subjects I at high risk of developing diabetes. Several immunologic and metabolic parameters have been studied to assess their reliability as predictors of 5 future development of diabetes in high risk individuals. Even if the combination of several of these factors proves to be highly specific in I defining the high risk individuals these studies require a lengthy follow-up period to ascertain their sensitivity and reliability in predicting impending diabetes.

Keywords

Major Histocompatibility Complex Beta Cell Islet Allograft Autoimmune Beta Cell Prediabetic Stage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kenneth L. Brayman
    • 1
  • James F. Markmann
    • 1
  • Clyde F. Barker
    • 1
  • Ali Naji
    • 1
  1. 1.Department of SurgeryUniversity of Pennsylvania, School of MedicinePhiladelphiaUSA

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