A New Marker of T Lymphocyte Activation in Type I Diabetes
Biological changes underlying T lymphocyte activation, are known to be complex and are still poorly understood (1). Prominent in the early activation-related phenomena (minutes to a few hours after the activation signal) are the elevation of cytoplasmic calcium and changes in transmembrane electrical potential (TMP) (2–4). Resting T lymphocytes possess a relatively constant TMP. However, following mitogen or antigen challenge, T cell TMP changes over several minutes to hours with consecutive periods of depolarization, repolarization and hyperpolarization (2). Selective membrane NA, K-ATP-ase, and the K and Na permeable channels, abrogate both the TMP changes and T cell activation indicating a relationship between them and suggesting that cell membrance depolarization is an integral part of cell activation (2).
KeywordsInsulin Dependent Diabetic Fluorescein Diacetate Islet Cell Antibody Insulin Dependent Diabetes Patient Fluorescence Intensity Profile
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