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Prediabetes pp 79-84 | Cite as

A New Marker of T Lymphocyte Activation in Type I Diabetes

  • John Cavanaugh
  • Neil E. Kay
  • Jaume Binimelis
  • Alberto de Leiva
  • Jose Barbosa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

Biological changes underlying T lymphocyte activation, are known to be complex and are still poorly understood (1). Prominent in the early activation-related phenomena (minutes to a few hours after the activation signal) are the elevation of cytoplasmic calcium and changes in transmembrane electrical potential (TMP) (2–4). Resting T lymphocytes possess a relatively constant TMP. However, following mitogen or antigen challenge, T cell TMP changes over several minutes to hours with consecutive periods of depolarization, repolarization and hyperpolarization (2). Selective membrane NA, K-ATP-ase, and the K and Na permeable channels, abrogate both the TMP changes and T cell activation indicating a relationship between them and suggesting that cell membrance depolarization is an integral part of cell activation (2).

Keywords

Insulin Dependent Diabetic Fluorescein Diacetate Islet Cell Antibody Insulin Dependent Diabetes Patient Fluorescence Intensity Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • John Cavanaugh
    • 1
    • 2
  • Neil E. Kay
    • 1
    • 2
  • Jaume Binimelis
    • 1
    • 2
  • Alberto de Leiva
    • 1
    • 2
  • Jose Barbosa
    • 1
    • 2
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineUniversity of MinnesotaMinneapolisUSA
  2. 2.Division of Hematology and Oncology Department of MedicineVeterans Administration Medical CenterMinneapolisUSA

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