History: The Discovery of Prediabetes in Animals

  • Virgilio G. Foglia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


In 1940 diabetes was produced in the rat by removal of the pancreas. Surgical mortality during operation as well as during the following weeks was only 10 to 20% and the survival time of the rats ranged from 4 to 11\(\frac{1}{2}\) months, maintained under standard diet (1). We were surprised to observe that even after 95% pancreatectomy, a few months elapsed before typical diabetes appeared.


Typical Diabetes Dental Caries Muscle Glycogen Surgical Mortality Pancreatic Acinus 
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  1. 1.
    Martinez, C., 1946, Influencia de la dieta sobre la diabetes de la rata. Rev Soc Argent Biol 22: 414–425.Google Scholar
  2. 2.
    Foglia, V.G., 1965, Prediabetes experimental. III Simp Panamer Farmac Terap Excerpta Med Intern Congr, Mexico, Series No. 127: 197–204.Google Scholar
  3. 3.
    Martin, J.M., Lacy, P.E., 1963, The prediabetic period in partially pancreatectomized rats. Diabetes 12: 238–242.Google Scholar
  4. 4.
    Foglia, V.G., 1970, Fetuses and newborns of 95% pancreatectomized female rats. In Early Diabetes, Gamerini Davalos and Cole, Eds., Academic Press, New York: 221–227.Google Scholar
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    Foglia, V.G., 1970, Experimental prediabetes. Proc VII Congr Intern Diabetes Fed Excerpta Intern Congr, Buenos Aires: 198–208.Google Scholar
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    Malgor, L.A., Foglia, V.G., Negro, Vilar A., 1963, Influencia de la pielonefritis experimental sobre el periodo de prediabetes de la rata. Rev Soc Argent Biol 39: 187–196.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Virgilio G. Foglia
    • 1
  1. 1.Instituto de Biologia y Medicina ExperimentalBuenos AiresArgentina

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