Control of Skin Wound Contraction Rate by Critically Insoluble Collagen Matrices

  • I. V. Yannas
  • E. Lee
  • M. Dionne Bentz
Part of the Polymer Science and Technology book series (PST, volume 38)


Several porous graft copolymers of collagen and chondroitin 6-sulfate were prepared and contacted with freshly excised subcutaneous muscle tissue in a standard guinea pig wound healing model. The degradation rate in collagenase of the copolymers was varied over a wide range by controlling the conditions of crosslinking in glutaraldehyde during polymer preparation. The average pore diameter was maintained at a constant level in the series. The kinetics of skin wound contraction were studied up to about 200 days following grafting with members of the series. We conclude that wound contraction is delayed significantly provided that the highly porous copolymers remain largely insoluble (undegraded) for a critical period following contact with tissue. The data are consistent with a requirement for an insolubility period of minimal duration. Although the absolute length of the critical period was not determined it was independently estimated at 10–15 days.


Degradation Rate Natural Rubber Graft Copolymer Average Pore Diameter Enzyme Unit 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • I. V. Yannas
    • 1
  • E. Lee
    • 1
  • M. Dionne Bentz
    • 1
  1. 1.Fibers and Polymers LaboratoriesMassachusetts Institute of TechnologyCambridgeUSA

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