Immune Modulating Effects of Poly(ICLC) in Mice, Monkeys and Man
The stabilized double stranded RNA, poly(ICLC), in addition to being an active interferon inducer, is able to modify a variety of humoral and cell associated immune activities in mice, monkeys and humans. In mice there is augmentation, in vitro and in vivo of macrophage activation and NK cell activity, as well as specific cytotoxic T cells. In primates, poly(ICLC) increases the amount and rapidity of formation of antibodies to a number of weak vaccines. In addition there is increased macrophage and 2′5′ A. synthetase activities. At low doses there is an augmentation of NK cell action, but inhibition at higher doses. Increases in T4/T8 ratio were found. Lymphocyte subset populations are modified in different ways, depending on the dose. In general low doses augment the several immune actions much better than do the higher doses.
KeywordsNatural Killer Cell Activity Mixed Lymphocyte Reaction Rift Valley Fever Rift Valley Fever Virus Venezuelan Equine Encephalitis Virus
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