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Synthesis of Antitumor Polysaccharides

  • Kei Matsuzaki
  • Iwao Yamamoto
  • Koji Enomoto
  • Yutaro Kaneko
  • Tohru Mimura
  • Tsuyoshi Shiio
Part of the Polymer Science and Technology book series (PST, volume 38)

Abstract

Previously, we have synthesized several antitumor polysaccharides having D-glucopyranose, D-mannopyranose, D-ara-binofuranose, or its oligomer, as side chains of (1→3)-β-glucan, or (1→4)-β-glucan by the orthoester method as models of natural antitumor polysaccharides, such as lentinan, etc. Some of these have indicated high antitumor activity against Sarcoma 180 implanted into mice, to the same extent as the natural polysaccharides. In this report, water soluble, branched polysaccharides having L-arabinofuranose or its oligomer, L-arabinopyranose, or D-galactopyranose as side chains were synthesized, and their structures and antitumor activities were determined, in order to investigate the effect of the kind of side chains on the antitumor activity. These synthetic polysaccharides showed high antitumor activity.

Keywords

Antitumor Activity Main Chain Methylation Analysis Glucose Unit High Antitumor Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kei Matsuzaki
    • 1
  • Iwao Yamamoto
    • 1
  • Koji Enomoto
    • 1
  • Yutaro Kaneko
    • 2
  • Tohru Mimura
    • 2
  • Tsuyoshi Shiio
    • 2
  1. 1.Faculty of Textile Science & TechnologyShinshu UniversityUeda 386Japan
  2. 2.Ajinomoto Co., Ltd.Chuo-ku Tokyo 104Japan

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