Advertisement

The Release of 5-Fluorouracil from Polycaprolactone Matrices

  • Charles G. Gebelein
  • Mark Chapman
  • Tahseen Mirza
Part of the Polymer Science and Technology book series (PST, volume 38)

Abstract

The release of 5-fluorouracil (5-FU) from monolithic dispersions in poly(caproiactone), [FUPC], was studied and compared with the release of 5-FU from the copolymers of 1-(N-2-ethylmethacryIcarbamoyl)-5-fluorouracil, [EMCF], with methyl methacrylate, [MMA]. Whereas the EMCF:MMA copolymers always exhibited zero-order release of the 5-FU (i.e., constant level of drug released with time), the [FUPC] systems did not. Up to about 25% 5-FU, the [FUPC] systems exhibited a profile in which the 5-FU release was dependent on the square root of time. On the other hand, the EMCF:MMA copolymers showed a constant release of the 5-FU regardless of whether the sample was in a powdered or a pellet form. The release rates were also slower for the copolymer systems than for the monolithic FUPC systems, and much higher concentrations of the drug could be incorporated into the copolymer systems. These differences in the release profiles are caused by differences in the basic nature of the two kinds of systems and the mechanisms of the release of the 5-FU from each. These differences and the mechanisms of the release are discussed in detail.

Keywords

Release Profile Methyl Methacrylate Internal Phase Pellet Form Second Order Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. G. Gebelein, R. M. Morgan, R. Glowacky & W. Baig in: “Biomedical & Dental Applications of Polymers”, C. G. Gebelein & F. F. Koblitz, Eds., Plenum Publ. Corp., New York, 1981, p. 191.Google Scholar
  2. 2.
    C. G. Gebelein in: “Biological Activities of Polymers”, C. E. Carraher, Jr. & C. G. Gebelein, Eds., American Chemical Society, Washington, DC, 1982, p. 193.CrossRefGoogle Scholar
  3. 3.
    C. G. Gebelein, Proc. Pplym. Mat. Sci. Eng., 51, 127–131 (1984).Google Scholar
  4. 4.
    R. R. Hartsough & C. G. Gebelein, Proc. Polym. Mat. Sci. Eng., 51, 131–135 (1984).Google Scholar
  5. 5.
    R. R. Hartsough & C. G. Gebelein in: “Polymerie Materials in Medication”, C. G. Gebelein & C. E. Carraher, Jr., Eds., Plenum Publ. Corp., New York, 1985, pp. 115–124.Google Scholar
  6. 6.
    C. G. Gebelein & R. R. Hartsough in: “Controlled Release of Bioactive Materials, 11th International Symposium”, W. £. Meyers & R. C. Dunn, Eds., Controlled Release Society, Lincolnshire, IL, 1984, pp. 65–66.Google Scholar
  7. 7.
    M. Yoshida, M. Kumakura & I. Kaetsu, Polymer, 19, 1375 (1978).CrossRefGoogle Scholar
  8. 8.
    M. Yoshida, M. Kumakura & I. Kaetsu, Polymer, 11, 775 (1979).CrossRefGoogle Scholar
  9. 9.
    I. Kaetsu, M. Yoshida, M. Kumakura, A. Yamada & Y. Sakurai, Biomaterials, 1, 17 (1980).CrossRefGoogle Scholar
  10. 10.
    I. Kaetsu, M. Yoshida & A. Yamada, J. Biomed. Mater. Res., 14, 185 (1980).CrossRefGoogle Scholar
  11. 11.
    C. G. Gebelem, R. R. Hartsough & T. Hirza in: “Controlled Release of Bioactive Materials, 13th International Symposium”, I. A. Chaudry & C. Thies.. Eds., Controlled Release Society, Lincolnshire, IL, 1986, pp. 188–189.Google Scholar
  12. 12.
    C. G. Gebelein, T. Mirza & R. R. Hartsough in: “Controlled Release Technology, Pharmaceutical Applications”, P. I. Lee & W. R. Good, Ed., American Chemical Society, Washington, DC, 1987, pp. 120–126.Google Scholar
  13. 13.
    T. Higuchi, J. Pharm. Sci., 59, 353 (1961).Google Scholar
  14. 14.
    Y. W. Chien, Ed., “Novel Drug Delivery Systems: Fundamentals, Developmental Concepts and Biomedical Assessments”, Marcel Dekker, New York, 1982.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Charles G. Gebelein
    • 1
  • Mark Chapman
    • 1
  • Tahseen Mirza
    • 1
  1. 1.Department of ChemistryYoungstown State UniversityYoungstownUSA

Personalised recommendations