Pharmacokinetic Analysis of (6S)-5-Formyltetrahydrofolate (1-CF), (6R)-5-Formyltetrahydrofolate (d-CF) and 5-Methyltetrahydrofolate (5-CH3-THF) in Patients Receiving Constant i.v. Infusion of High-Dose (6R,S)-5-Formyltetrahydrofolate (Leucovorin)
The biochemical rationale for the combination of leucovorin and fluorouracil presumes that administration of large doses of leucovorin will increase the endogenous pools of active folates and enhance the formation and/or stability of the thymidylate synthase-FdUMP-methylenetetrahydrofolate complex (1). A knowledge of the pharmacokinetic behavior of leucovorin and its active metabolite is essential if one is to select doses of leucovorin which will produce adequate plasma levels of active folates.
KeywordsPlasma Clearance Constant Infusion Pharmacokinetic Behavior Tetrabutylammonium Hydroxide Nonrenal Clearance
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