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Clinical Experience with 5-FU/DDP ± OHDW Combination Chemotherapy in Patients with Advanced Colorectal Carcinoma

  • Stefan Madajewicz
  • John J. Fiore
  • Mohammad H. Zarrabi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

Many avenues are being explored in an effort to develop more effective and selective treatment of patients with advanced colorectal carcinoma. One approach termed biochemical modulation is based on “immortal”, although minimal, 5-fluorouracil (5-FU) activity. At least six types of modulation have been attempted based on the current understating of 5-FU metabolism: 1) Methotrexate, 2) Thymidine, 3) PALA, 4) Allopurinol, 5) Folinic acid (FA), and 6) cisPlatin (DDP).

Keywords

Lung Metastasis Folinic Acid Advanced Colorectal Cancer Methionine Metabolism Biochemical Modulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Stefan Madajewicz
    • 1
  • John J. Fiore
    • 1
  • Mohammad H. Zarrabi
    • 1
  1. 1.Division of Oncology, Health Sciences CenterState University of New York at Stony BrookStony BrookUSA

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