5-Fluorouracil and 5-Formyltetrahydrofolate in Advanced Malignancies
As conventional FUra monochemotherapy with remission rates of about 20% remained disappointing, the addition of CF to FUrd heralded an important step towards an improved therapy of advanced colorectal cancer (1). In a broad phase II study we evaluated response, toxicity and survival of patients receiving combination treatment of FUra and CF, primarily in colorectal cancer. In addition we treated pts with prostatic cancer, breast cancer, gastric cancer and various other poor risk malignancies with this combination. We used two different schedules of FUrd and CF. Our data indicate improved response in colorectal cancer as compared to FUra alone and are promising in breast cancer and adenocarcinoma of unknown primary.
KeywordsBreast Cancer Prostatic Cancer Gastric Cancer Colorectal Cancer Gastric Adenocarcinoma
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