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5-Fluorouracil and 5-Formyltetrahydrofolate in Advanced Malignancies

  • Reinhard Becher
  • Erhard Kurschel
  • Ursula Wandl
  • Otto Kloke
  • Max Scheulen
  • Olivia Weinhardt
  • Klaus Höffken
  • Norbert Niederle
  • Hakeem Khan
  • Stefan Bergner
  • Wolfgang Sauerwein
  • Ursula Rüther
  • Carl G. Schmidt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

As conventional FUra monochemotherapy with remission rates of about 20% remained disappointing, the addition of CF to FUrd heralded an important step towards an improved therapy of advanced colorectal cancer (1). In a broad phase II study we evaluated response, toxicity and survival of patients receiving combination treatment of FUra and CF, primarily in colorectal cancer. In addition we treated pts with prostatic cancer, breast cancer, gastric cancer and various other poor risk malignancies with this combination. We used two different schedules of FUrd and CF. Our data indicate improved response in colorectal cancer as compared to FUra alone and are promising in breast cancer and adenocarcinoma of unknown primary.

Keywords

Breast Cancer Prostatic Cancer Gastric Cancer Colorectal Cancer Gastric Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Reinhard Becher
    • 1
  • Erhard Kurschel
    • 1
  • Ursula Wandl
    • 1
  • Otto Kloke
    • 1
  • Max Scheulen
    • 1
  • Olivia Weinhardt
    • 1
  • Klaus Höffken
    • 1
  • Norbert Niederle
    • 1
  • Hakeem Khan
    • 1
  • Stefan Bergner
    • 2
  • Wolfgang Sauerwein
    • 3
  • Ursula Rüther
    • 4
  • Carl G. Schmidt
    • 1
  1. 1.Innere Universitätsklinik (Tumorforschung)Germany
  2. 2.Urologische KlinikGermany
  3. 3.StrahlenklinikGermany
  4. 4.Westdeutsches TumorzentrumUnivirsitätsklinikum EssenStuttgartGermany

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