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A Randomized Trial of 5-Fluorouracil Alone Versus 5-Fluorouracil and High Dose Leucovorin in Untreated Advanced Colorectal Cancer Patients

  • M. T. Nobile
  • L. Canobbio
  • A. Sobrero
  • E. Galligioni
  • M. G. Vidili
  • T. Fassio
  • G. Lo Re
  • A. Rubagotti
  • M. R. Sertoli
  • R. Rosso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

It has been experimentally proven that high doses of the reduced folate leucovorin (LV) enhance the therapeutic efficacy of 5-fluorouracil (5FU) by increasing the FdUMP-TS binding. This rationale prompted various phase II clinical trials whose results apparently showed enhancement of the 5FU antitumor activity.

Keywords

Maximum Tolerate Dose Remission Rate Dose Intensity Minor Response Primary Tumor Colon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • M. T. Nobile
    • 1
  • L. Canobbio
    • 1
  • A. Sobrero
    • 1
  • E. Galligioni
    • 2
  • M. G. Vidili
    • 1
  • T. Fassio
    • 2
  • G. Lo Re
    • 2
  • A. Rubagotti
    • 1
  • M. R. Sertoli
    • 1
  • R. Rosso
    • 2
  1. 1.Istituto Nazionale per la Ricerca sul CancroGenovaItaly
  2. 2.Centro di riferimento OncologicoAviano, PordenoneItaly

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