A Randomized Trial of 5-Fluorouracil Alone Versus 5-Fluorouracil and High Dose Leucovorin in Untreated Advanced Colorectal Cancer Patients
It has been experimentally proven that high doses of the reduced folate leucovorin (LV) enhance the therapeutic efficacy of 5-fluorouracil (5FU) by increasing the FdUMP-TS binding. This rationale prompted various phase II clinical trials whose results apparently showed enhancement of the 5FU antitumor activity.
KeywordsMaximum Tolerate Dose Remission Rate Dose Intensity Minor Response Primary Tumor Colon
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