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Defective Ca2+ Functions in Protein (47-kDa) Phosphorylation and in the Coupling to Physiological Responses in Platelets from Stroke-Prone Spontaneously Hypertensive Rats

  • Takako Tomita
  • Keizou Umegaki
  • Masahiko Ikeda
  • Nobuaki Takeshita
  • Kazuki Nakamura
  • Yasuhide Inoue
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Although hypertension is assumed to be one of the important factors in thrombotic disease, inconsistent reports have been presented concerning changes in platelet function due to hypertension. Stroke-prone spontaneously hypertensive rats (SHRSP), a substrain of spontaneously hypertensive rats (SHR), which was established in 1974 (Okamotoet al., 1974), develops more severe hypertension spontaneously than SHR, and dies of massive cerebral hemorrhage or infarction between 100 and 300 days after birth. Changes in platelet functions were investigated using these strains of spontaneous hypertension which are considered to represent the closest model to human hypertension. In addition, platelets are a tissue in which pathophysiological changes are intimately related to those of blood vessels (Mustardet al., 1964). Both contain contractile proteins and Ca2+ plays important roles in both tissues (Weiss, 1975). Thus, the study of abnormalities in platelets from hypertensive animals may shed light on the etiology of hypertension as well as of diseases consequent to hypertension.

Keywords

Platelet Function Protein Phosphorylation Serotonin Release Inositol Trisphosphate Phenacyl Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Takako Tomita
    • 1
  • Keizou Umegaki
    • 1
  • Masahiko Ikeda
    • 1
  • Nobuaki Takeshita
    • 1
  • Kazuki Nakamura
    • 1
  • Yasuhide Inoue
    • 1
  1. 1.Department of PharmacologyUniversity of Shizuoka School of Pharmaceutical SciencesShizuokaJapan

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