Interaction of Volatile Anesthetics with Calcium-Sensitive Sites in the Myocardium
There are a number of inhaled agents that can produce general anesthesia. They are known as volatile anesthetics (VA). Three of the most commonly used VA are halothane (CF3CHBrCl), enflurane (CFHClCF2OCHF2), and isoflurane (CF3CHClOCHF2). They are effective and safe anesthetics, but their major side effect is a concentration-dependent depression of cardiac contractility (Brown and Crout, 1971). The depression of contractility, like anesthesia itself, is amazingly reversible but can have serious hemodynamic consequences in patients with cardiac disease, vascular abnormalities, and other organ system malfunctions. In these cases, the depression of cardiac contractility can result in dangerous metabolic imbalances.
KeywordsSarcoplasmic Reticulum Calcium Uptake Cardiac Contractility Volatile Anesthetic Halothane Concentration
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