Role of Membrane Dysfunction and Altered Calcium Homeostasis in the Pathogenesis of Irreversible Myocardial Injury

  • L. Maximilian Buja
  • James T. Willerson
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The initial consequences of impaired coronary blood flow in the ischemic myocardium are decreased oxygen-dependent energy metabolism, decreased high-energy phosphate content, acidosis, accumulation of lactate and other metabolites, K+ efflux, electromechanical uncoupling, and depressed myocardial function. A major issue is how the initial metabolic alterations, if they persist, lead to irreversible myocardial injury or necrosis. A large body of evidence supports the conclusions that progressive membrane damage, including damage to the sarcolemma and organellar membranes, is the essential factor in the conversion from reversible to irreversible injury in myocardial ischemia and related conditions, and that altered calcium homeostasis may have an important role in the pathogenesis of the membrane damage (Nayler, 1981).


Calcium Overload Membrane Injury Permeability Defect Iodoacetic Acid Irreversible Injury 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • L. Maximilian Buja
    • 1
  • James T. Willerson
    • 1
  1. 1.Department of PathologyUniversity of Texas Southwestern Medical Center at DallasDallasUSA

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