Role of Phosphoinositides in the Response of Mammalian Cells to Heat Shock
All cellular organisms possess a profound response to temperature shock which consists of the expression of a group of phylogenetically well-preserved genes, the heat shock genes (Lindquist, 1986; Pelham, 1986). They are among the most highly conserved of all known genes. The response appears to be homeostatic in nature leading to heat resistance (Lindquist, 1986). In animal cells, the heat shock response leads to profound changes at the level of transcription (Parker and Topol, 1984; Pelham, 1986), RNA processing (Toot and Lindquist, 1986), translation (Duncanet al., 1987), and intracellular protein transport (Napolitanoet al., 1987). The biochemical regulation of these effects is not understood.
KeywordsHeat Shock Heat Shock Response Inositol Phosphate Heat Shock Gene Inositol Trisphosphate
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