Molecular Properties of Dihydropyridine Sensitive Calcium Channels
In muscle tissues, voltage-sensitive calcium channels mediate calcium influx during cellular depolarization and play an important role in excitation-contraction coupling (reviewed by Reuter, 1979; Hagiwara and Byerly, 1981). In neurons, they produce action potentials in dendrites (Schwartzkroin and Slawsky, 1977; Llinaset al., 1981) and couple changes in membrane potential at nerve terminals to the release of neurotransmitter (Katz and Miledi, 1969). Multiple classes of calcium channels have been distinguished in neurons (Carbone and Lux, 1984; Armstrong and Matteson, 1985; Nowyckyet al., 1985) and in cardiac muscle cells (Niliuset al., 1985; Bean, 1985). This article focuses on molecular properties of calcium channels that are blocked by dihydropyridine calcium antagonists. These are the most prom inent calcium channels in smooth, cardiac, and skeletal muscle and they are also present in neurons and neurosecretory cells.
KeywordsCalcium Channel Photoaffinity Label Dihydropyridine Receptor Calcium Channel Subunit Phosphatidylcholine Vesicle
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