Molecular Properties of Dihydropyridine Sensitive Calcium Channels

  • William A. Catterall
  • Michael J. Seagar
  • Masami Takahashi
  • Benson M. Curtis
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


In muscle tissues, voltage-sensitive calcium channels mediate calcium influx during cellular depolarization and play an important role in excitation-contraction coupling (reviewed by Reuter, 1979; Hagiwara and Byerly, 1981). In neurons, they produce action potentials in dendrites (Schwartzkroin and Slawsky, 1977; Llinaset al., 1981) and couple changes in membrane potential at nerve terminals to the release of neurotransmitter (Katz and Miledi, 1969). Multiple classes of calcium channels have been distinguished in neurons (Carbone and Lux, 1984; Armstrong and Matteson, 1985; Nowyckyet al., 1985) and in cardiac muscle cells (Niliuset al., 1985; Bean, 1985). This article focuses on molecular properties of calcium channels that are blocked by dihydropyridine calcium antagonists. These are the most prom inent calcium channels in smooth, cardiac, and skeletal muscle and they are also present in neurons and neurosecretory cells.


Calcium Channel Photoaffinity Label Dihydropyridine Receptor Calcium Channel Subunit Phosphatidylcholine Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • William A. Catterall
    • 1
  • Michael J. Seagar
    • 1
  • Masami Takahashi
    • 1
    • 2
  • Benson M. Curtis
    • 1
  1. 1.Department of PharmacologyUniversity of WashingtonSeattleUSA
  2. 2.Mitsubishi, Kasei Institute of Life SciencesMachida-ShiJapan

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