Mechanisms of Anoxic Injury to Transport and Metabolism of Proximal Renal Tubules
The pathological effects of ischemia have been extensively studied in the kidney (e.g., Venkatachalamet al., 1978; Trumpet al., 1982; Johnstonet al., 1984). By subjecting the kidney to ischemia of varying duration, investigators have been able to describe the many morphological, physiological, and biochemical alterations that occur in the kidney as a function of time. Upon deprivation of oxygen, proximal tubules rapidly lose K, gain Na, and decrease their ATP content. Within 15 min of clamp-induced ischemia, structural alterations are clearly observed in the form of cellular and mitochondrial swelling and irregular brush borders. At the same time, mitochondrial dysfunctions are clearly discernible (Kahnget al., 1978).
KeywordsAdenine Nucleotide Proximal Renal Tubule Electron Probe Analysis Urinary Bladder Epithelial Cell Adenine Nucleotide Content
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