Role of Ion Regulation in Cell Injury, Cell Death, and Carcinogenesis

  • Benjamin F. Trump
  • Irene K. Berezesky
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The understanding of acute and chronic cell injury constitutes one of the major problems in medical science, involving such issues as the mechanism of cell death and the control of cell growth and differentiation. Disease represents the summation of the effects of responses to cell injury in multicellular forms. Cell injury can be classified into those injuries that lead to cell death preceded by a reversible phase and those injuries that result in altered steady states compatible with cell survival, though in a different form (Trump and Arstila, 1971). We have observed that the responses to acute as well as to chronic cell injuries are accom panied by changes in cell ion content, including cytosolic sodium ([Na+ ]i), potassium ([K+ ]i), chloride ([Cl- ]i), magnesium ([Mg2+ ]i), and calcium ([Ca2+ ]i) (Trumpet al., 1971). In the present paper, we will continue to explore our hypothesis that deregulation of free, ionized cytosolic [Ca2+ ]i is directly or indirectly related to many of the events that follow acute cell injury as well as to control of cell division and differentiation (Trump and Berezesky, 1985, l987a-c; Trumpet al., 1984).


Cell Injury Ehrlich Ascites Tumor Cell Proximal Tubular Epithelial Cell Emergency Medical Service System Bleb Formation 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Benjamin F. Trump
    • 1
    • 2
  • Irene K. Berezesky
    • 1
    • 2
  1. 1.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.The Maryland Institute for Emergency Medical Services SystemsBaltimoreUSA

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