Origin and Role of Calcium in Platelet Activation-Contraction-Secretion Coupling

  • Gundu H. R. Rao
  • Jonathan M. Gerrard
  • Isaac Cohen
  • Carl J. WitkopJr.
  • James G. White
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Agonist interaction with platelet surface receptors initiates a complex but concerted series of events inducing alterations in morphology, biochemistry, and physiology (White, 1968; Marcus, 1978; Holmsen and Weiss, 1979; Zucker and Nachmias, 1985). Intracellular move ments of calcium ions accompany and may play a critical role in regulating these biochemical and physiological processes (Statlandet al., 1969; Feinman and Detwiler, 1974; Hathaway and Adelstein, 1979; Feinstein, 1980; Gerrardet al., 1981; Foxet al., 1983; Menahsiet al., 1984). For lack of precise methods to monitor intracellular free calcium, earlier studies relied heavily on indirect methods to demonstrate agonist-induced calcium mobilization. However, synthesis of novel calcium indicators has made it possible to demonstrate agonistinduced calcium mobilization concurrent with cell activation (Rinket al., 1982; Grynkiewiczet al., 1985; Raoet al., 1985a,b).


Dense Body Cytosolic Calcium Irreversible Aggregation Clot Retraction Platelet Secretion 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Gundu H. R. Rao
    • 1
  • Jonathan M. Gerrard
    • 2
  • Isaac Cohen
    • 3
  • Carl J. WitkopJr.
    • 4
  • James G. White
    • 1
  1. 1.Department of Laboratory Medicine and PathologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of PediatricsUniversity of ManitobaWinnepegCanada
  3. 3.Artherosclerosis Research LaboratoryNorthwestern UniversityChicagoUSA
  4. 4.Department of Human and Oral GeneticsUniversity of Minnesota School of DentistryMinneapolisUSA

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