Role of Calcium in the Regulation of Mammalian Lipoxygenases
Arachidonic acid is the precursor to a variety of oxygenated metabolites that have been implicated as regulators of various cell functions. The prostanoids are one group of metab olites that are formed from arachidonic acid via the cyclooxygenase pathway. Arachidonic acid metabolism catalyzed by the lipoxygenase pathway, which produces metabolites such as hydroperoxyeicosatetraenoic acids (HPETEs), the corresponding hydroxy analogs (HETEs), leukotrienes (LTs), and lipoxins (Pace-Asciak and Smith, 1983), will be the focus of this paper. Our laboratory as well as others has shown that the HETEs can modulate cellular lipoxygenase, cyclooxygenase, and phospholipase activities (Vanderhoek, 1985). LTB4causes leukocyte adhesion, degranulation and chemotaxis of neutrophils while LTC4, LTD4, and LTE4, which are released during an anaphylactic reaction, cause broncho-and vasoconstriction and an increase in vascular permeability (Samuelsson, 1983). Lipoxin A causes a contraction of bronchial smooth muscle while lipoxins A and B can inhibit natural killer cell function without preventing natural killer cell binding to target cells (Samuelsson, 1987).
KeywordsArachidonic Acid Phorbol Myristate Acetate Cytosolic Calcium Level Exogenous Arachidonic Acid Hydroperoxyeicosatetraenoic Acid
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