Calcium Pulses, Waves, and Gradients in Early Development

  • Lionel F. Jaffe
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Free Ca2+ ions are among the half dozen or so small ions or molecules whose changing patterns within cells is in immediate control of their growth, development, behavior, and death. This chapter focuses on the role of free Ca2+ in activating eggs and in the development of pattern.


Free Calcium Calcium Wave Inositol Trisphosphate Vertebrate Line Sand Dollar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Berridge, M. J., 1987, Inositol trisphosphate and diacylglycerol: Two interacting second messengers, Ann. Rev. Biochem. 56:159–193.PubMedCrossRefGoogle Scholar
  2. Brawley, S. J., and Robinson, K. R., 1985, Cytochalasin treatment disrupts the endogenous currents associated with cell polarization in fucoid zygotes, J. Cell Biol. 100:1173–1184.PubMedCrossRefGoogle Scholar
  3. Brownlee, C., and Wood, J. W., 1986, A gradient of cytoplasmic free calcium in growing rhizoid cells of Fucus serratus, Nature 320:624–626.CrossRefGoogle Scholar
  4. Busa, W. B., and Nuccitelli, R., 1985, An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis, J. Cell Biol. 100:1325–1329.PubMedCrossRefGoogle Scholar
  5. Child, C. M., 1941, Patterns and Problems of Development ,University of Chicago Press, Chicago.CrossRefGoogle Scholar
  6. Eckert, R., and Chad, J. E., 1984, Inactivation of Ca channels, Prog. Biophys. Molec. Biol. 44: 215–267.CrossRefGoogle Scholar
  7. Gilkey, J. C., Jaffe, L. J., Ridgway, E. B., and Reynolds, G. T., 1978, A free calcium wave traverses the activating medaka egg, J. Cell Biol. 76:448–466.PubMedCrossRefGoogle Scholar
  8. Hafner, M., Petzelt, C., Nobiling, R., Pawley, J. B., Kramp, D., and Schatten, G., 1988, Wave of free calcium at fertilization in the sea urchin egg visualized with Fura-2, Cell Motility and the Cytoskeleton ,9:271–277.PubMedCrossRefGoogle Scholar
  9. Haugland, R. P., 1985, Molecular Probes Handbook of Fluorescent Probes ,Molecular Probes, Junction City, Oregon.Google Scholar
  10. Jaffe, L. F., 1982, Developmental current, voltages, and gradients, Symp. Soc. Dev. Biol. 40:183–218.Google Scholar
  11. Jaffe, L. F., 1983, Sources of calcium in egg activation. A review and hypothesis, Dev. Biol. 99: 267–276.CrossRefGoogle Scholar
  12. Jaffe, L. F., 1985, The role of calcium explosions, waves, and pulses, in activating eggs, in: Biology of Fertilization ,Vol. 3 (C. B. Metz and A. Monroy, eds.), Academic Press, New York, pp. 127–165.Google Scholar
  13. Jaffe, L. F., 1986, Calcium and morphogenetic fields, CIBA Symp. 122:217–288.Google Scholar
  14. Kubota, H. Y., Yoshimoto, Y., Yoneda, M., and Hiramoto, Y., 1987, Free calcium wave upon activation in Xenopus eggs, Dev. Biol. 119:129–136.PubMedCrossRefGoogle Scholar
  15. Miyazaki, S-L, Hashimoto, N., Yoshimoto, Y., Kishimoto, T., Igusa, Y., and Hiramoto, Y., 1986, Temporal and spatial dynamics of the periodic increase in intracellular free calcium at fertilization of golden hamster eggs, Dev. Biol. 118:259–267.PubMedCrossRefGoogle Scholar
  16. Nuccitelli, R., and Jaffe, L. F., 1974, Spontaneous current pulses through developing fucoid eggs, Proc. Natl. Acad. Sci. USA 71:4855–4859.PubMedCrossRefGoogle Scholar
  17. Oberdorf, J. A., Head, J. A., and Kaminer, B., 1986, Calcium uptake and release by isolated cortices and microsomes from the unfertilized egg of the sea urchin Strongylocentrotus droebachiensis, J. Cell Biol. 102:2205–2210.PubMedCrossRefGoogle Scholar
  18. Speksnijder, J. E., Corson, D. W., Jaffe, L. F., and Sardet, C., 1986, Calcium pulses and waves through ascidian eggs, Biol. Bull. 171:488.Google Scholar
  19. Swann, K., and Whitaker, M., 1986, The part played by inositol trisphosphate and calcium in the propagation of the fertilization wave in sea urchin eggs, J. Cell Biol. 103:2333–2342.PubMedCrossRefGoogle Scholar
  20. Tsien, R. Y., 1980, New calcium indicators and buffers with high selectivity against magnesium and protons, Biochemistry 19:2396–2404.PubMedCrossRefGoogle Scholar
  21. Turner, P. R., Jaffe, L. A., and Fein, A., 1986, Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein, J. Cell Biol. 102:70–76.PubMedCrossRefGoogle Scholar
  22. Whitaker, M. J., and Irvine, R. F., 1984, Inositol (1,4,5) trisphosphate microinjection activates sea urchin eggs, Nature 312:636–639.CrossRefGoogle Scholar
  23. Woods, N. M., Cuthbertson, K. S. R., and Cobbold, P. H., 1987, Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes, Cell Calcium 8:79–100.PubMedCrossRefGoogle Scholar
  24. Yoshimoto, Y., Iwamatsu, T., Hirano, K.-I., and Hiromoto, Y., 1986, The wave pattern of free calcium release upon fertilization in medaka and sand dollar eggs, Develop. Growth and Differ. 28:583–596.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Lionel F. Jaffe
    • 1
  1. 1.Marine Biological LaboratoryWoods HoleUSA

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