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Role and Properties of Ligand-Induced Calcium Fluxes in Lymphocytes

  • Sergio Grinstein
  • Stephen Macdougall
  • Roy K. Cheung
  • Erwin W. Gelfand
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Binding of foreign antigens to the surface of resting B lymphocytes activates and induces them to proliferate, producing an expanded and functionally responsive population.In vitro, the initial steps of this activation process can be mimicked by crosslinking surface immunoglobulins (Ig), which function as antigen receptors on the plasma membrane of B lym phocytes. Crosslinking can be readily achieved using antibodies directed against Ig (anti-Ig). In most of the experiments discussed below, human tonsillar B cells were activated with antibodies against IgM, which is present on the surface of over 60% of the cells.

Keywords

Intracellular Store Internal Store Plasma Membrane Potential Surface Immunoglobulin Sustained Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Sergio Grinstein
    • 1
  • Stephen Macdougall
    • 1
  • Roy K. Cheung
    • 1
  • Erwin W. Gelfand
    • 1
  1. 1.Divisions of Cell Biology and Immunology and Rheumatology, Research Institute, Hospital for Sick Children, Department of BiochemistryUniversity of TorontoCanada

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