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Small Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger

  • Terry W. Moody
  • Anne N. Murphy
  • Samira Mahmoud
  • Gary Fiskum
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Neuropeptide receptors mediate their action through the use of second messenger systems. Vasoactive intestinal polypeptide (VIP) and secretin, which are 28 and 27 amino acid peptides, respectively, utilize cAMP as a second messenger (Jensen and Gardner, 1984). Each of these peptides binds to distinct polypeptide receptors which are coupled to a stimulatory guanine nucleotide regulatory subunit (Ns) which interacts positively with the membranebound enzyme adenylate cyclase. In contrast, somatostatin (SRIF) receptors interact with an inhibitory guanine nucleotide regulatory subunit (Ni) which interacts negatively with adenyl ate cyclase.

Keywords

Vasoactive Intestinal Polypeptide Pancreatic Acinar Cell Small Cell Lung Cancer Cell Autocrine Growth Factor Human Small Cell Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Terry W. Moody
    • 1
  • Anne N. Murphy
    • 1
  • Samira Mahmoud
    • 1
  • Gary Fiskum
    • 2
  1. 1.Department of BiochemistryGeorge Washington University School of Medicine and Health SciencesUSA
  2. 2.Departments of Biochemistry and Emergency MedicineGeorge Washington University School of Medicine and Health SciencesUSA

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