Small Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger
Neuropeptide receptors mediate their action through the use of second messenger systems. Vasoactive intestinal polypeptide (VIP) and secretin, which are 28 and 27 amino acid peptides, respectively, utilize cAMP as a second messenger (Jensen and Gardner, 1984). Each of these peptides binds to distinct polypeptide receptors which are coupled to a stimulatory guanine nucleotide regulatory subunit (Ns) which interacts positively with the membranebound enzyme adenylate cyclase. In contrast, somatostatin (SRIF) receptors interact with an inhibitory guanine nucleotide regulatory subunit (Ni) which interacts negatively with adenyl ate cyclase.
KeywordsVasoactive Intestinal Polypeptide Pancreatic Acinar Cell Small Cell Lung Cancer Cell Autocrine Growth Factor Human Small Cell Lung Cancer
Unable to display preview. Download preview PDF.
- Carney, D. N., Cuttitta, F., Moody, T. W., and Minna, J. D., 1987, Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin releasing peptides, Cancer Res. 46: 1214–1218.Google Scholar
- Jensen, R. T., and Gardner, J. D., 1984, Identification and characterization of receptors for secretagogues on pancreatic acinar cells, Fed. Proc. 40:2486–2496.Google Scholar
- Jensen, R. T., and Gardner, J. D., 1986, Structure-function studies of agonists and antagonists for gastrointestinal peptide receptors on pancreatic acinar cells, in Neural and Endocrine Peptides and Receptors (Moody, T. W., ed.), Plenum Press, New York, pp. 485–500.Google Scholar
- Korman, L. Y., Carney, D. N., Citron, M. L., and Moody, T. W., 1986, Secretin/VIP stimulated secretion of bombesin-like peptides from human small cell lung cancer, Cancer Res. 47:821–825.Google Scholar
- Mendoza, S. A., Schneider, J. A., Lopez-Rivas, A., Sinnet-Smith, J. W., and Rozengurt, E., 1986, Early events elicited by bombesin and structurally related peptides in quiescent swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na + K+ pump activity and intracellular pH, J. Cell Biol. 102:2223–2233.PubMedCrossRefGoogle Scholar
- Moody, T. W., Mahmoud, S., Koros, A., Cuttitta, F., Willey, J., Rotsch, M., Zeymer, U., and Bepler, G., 1987a, Substance P analogues antagonize small cell lung cancer bombesin receptors, Fed. Proc. 46:2201.Google Scholar
- Zachary, I., Sinnett-Smith, J. W., and Rozengurt, E., 1986, Early events solicited by bombesin and structurally related peptides in quiescent swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding, J. Cell. Biol. 102:2211–2222.PubMedCrossRefGoogle Scholar