Abstract
Neuropeptide receptors mediate their action through the use of second messenger systems. Vasoactive intestinal polypeptide (VIP) and secretin, which are 28 and 27 amino acid peptides, respectively, utilize cAMP as a second messenger (Jensen and Gardner, 1984). Each of these peptides binds to distinct polypeptide receptors which are coupled to a stimulatory guanine nucleotide regulatory subunit (Ns) which interacts positively with the membranebound enzyme adenylate cyclase. In contrast, somatostatin (SRIF) receptors interact with an inhibitory guanine nucleotide regulatory subunit (Ni) which interacts negatively with adenyl ate cyclase.
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© 1989 Plenum Press, New York
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Moody, T.W., Murphy, A.N., Mahmoud, S., Fiskum, G. (1989). Small Cell Lung Cancer Bombesin Receptors Utilize Calcium as a Second Messenger. In: Fiskum, G. (eds) Cell Calcium Metabolism. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5598-4_29
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DOI: https://doi.org/10.1007/978-1-4684-5598-4_29
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