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Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2+ Mobilization in the Human Platelet

  • Michael F. Crouch
  • Eduardo G. Lapetina
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

In many mammalian cell types, stimulation of specific receptors by agonists is accompanied by a nonvoltage-regulated mobilization of intracellular Ca2+ stores. This results in the elevation of the cytosolic Ca2+ concentration, which can evoke cellular responses such as, in the platelet, secretion, shape change, and aggregation. The Ca2+ appears to originate from specific, nonmitochondrial sites in the cell, probably endoplasmic reticulum or the platelet-dense tubular system.

Keywords

Human Platelet Receptor Desensitization Thrombin Action Inositol Trisphosphate Thrombin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael F. Crouch
    • 1
  • Eduardo G. Lapetina
    • 2
  1. 1.Department of PharmacologyAustralian National UniversityCanberraAustralia
  2. 2.Division of Cell BiologyBurroughs Wellcome Co.Research Triangle ParkUSA

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