Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2+ Mobilization in the Human Platelet
In many mammalian cell types, stimulation of specific receptors by agonists is accompanied by a nonvoltage-regulated mobilization of intracellular Ca2+ stores. This results in the elevation of the cytosolic Ca2+ concentration, which can evoke cellular responses such as, in the platelet, secretion, shape change, and aggregation. The Ca2+ appears to originate from specific, nonmitochondrial sites in the cell, probably endoplasmic reticulum or the platelet-dense tubular system.
KeywordsHuman Platelet Receptor Desensitization Thrombin Action Inositol Trisphosphate Thrombin Receptor
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