Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2+ Mobilization in the Human Platelet

  • Michael F. Crouch
  • Eduardo G. Lapetina
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


In many mammalian cell types, stimulation of specific receptors by agonists is accompanied by a nonvoltage-regulated mobilization of intracellular Ca2+ stores. This results in the elevation of the cytosolic Ca2+ concentration, which can evoke cellular responses such as, in the platelet, secretion, shape change, and aggregation. The Ca2+ appears to originate from specific, nonmitochondrial sites in the cell, probably endoplasmic reticulum or the platelet-dense tubular system.


Human Platelet Receptor Desensitization Thrombin Action Inositol Trisphosphate Thrombin Receptor 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael F. Crouch
    • 1
  • Eduardo G. Lapetina
    • 2
  1. 1.Department of PharmacologyAustralian National UniversityCanberraAustralia
  2. 2.Division of Cell BiologyBurroughs Wellcome Co.Research Triangle ParkUSA

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