Extrinsic Determinants of Retinal Ganglion Cell Development in Cats and Monkeys
Vision in vertebrates is subserved by a number of specialized channels that function in parallel in order to extract simultaneously a variety of features of the environment (reviewed by Stone et al, 1979). As with all things visual, these parallel pathways begin in the retina. The mammalian retina contains a variety of ganglion cell types which have different forms, functional properties, and central projections (Enroth-Cugell and Robson, 1966; Boycott and Wässle, 1974; Cleland and Levick, 1974a,b; Stone and Fukuda, 1974). The developmental processes through which neurons in general and ganglion cells in particular differentiate into distinct types have recently begun to be explored (Eysel et al, 1985; Kirby and Chalupa, 1986; Maslim et al, 1986; Ramoa et al, 1987; Leventhalet al, 1988a,b). Both intrinsic (genetic) factors and extrinsic influences of the cell’s environment appear to mediate the determination of adult cell type.
KeywordsBeta Cell Ganglion Cell Retinal Ganglion Cell Alpha Cell Dendritic Field
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