Ultrastructure of the Myometrium

  • W. C. Cole
  • R. E. Garfield


The concept that a well-developed appreciation of structure is an essential prerequisite to an understanding of function permeates research into all physical processes but is especially true for the biological sciences. The electron microscopic and x-ray diffraction studies conducted on the myometrium during the past 25 years have provided important insights into the physiology of this organ. This chapter reviews our understanding of the ultrastructure of the myometrium. Particular emphasis is placed on the development and functional significance of gap junctions between myometrial cells, a topic not covered in previous editions of this book because of its relatively recent development. We believe that the observation that gap junctions appear in large numbers between myometrial cells during the onset and progression of labor (Garfield et al., 1977) was a major step forward in our understanding of the circumstances that control parturition. We also provide a detailed description of the structure of the contractile apparatus and its relationship to the plasma membrane and cytoskeleton. Several important observations have been made in this area since the last edition of this book.


Smooth Muscle Smooth Muscle Cell Dense Body Thin Filament Dense Band 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • W. C. Cole
    • 1
  • R. E. Garfield
    • 2
    • 3
  1. 1.Division of Cardiovascular Sciences, St. Boniface Research Institute, Department of PhysiologyUniversity of ManitobaWinnipegCanada
  2. 2.Department of NeurosciencesMcMaster University, Health SciencesHamiltonCanada
  3. 3.Department of Obstetrics and GynecologyMcMaster University, Health SciencesHamiltonCanada

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