Endometrial Hyperplasia and Neoplasia

  • Alex Ferenczy
  • Christine Bergeron


The pathogenesis of endometrial hyperplasia and its relationship to carcinoma have long been issues of concern to students of endometrial pathology (Hertig and Sommers, 1949; Hertig et al., 1949; Beutler et al., 1963; Gusberg and Kaplan, 1963; Vellios, 1972; Gusberg et al., 1974; Welch and Scully, 1977; Tavassoli and Kraus, 1978; Fox and Buckley, 1982; Ferenczy et al., 1983; Kurman et al., 1985; Ferenczy, 1988). More specifically, the morphological diagnosis, the potential for invasive carcinoma, and the appropriate treatment of hyperplastic endometria remain hotly debated and controversial subjects. Difficulties in obtaining consensus have resulted from several complex factors, both morphological and clinical. For example, histologically benign endometrial glands may present with worrisome architecture, mimicking malignancy, whereas glandular cells with a benign appearance or very subtle cytological modifications may demonstrate extensive invasive growth patterns of well-differentiated carcinoma.


Endometrial Cancer Invasive Carcinoma Endometrial Carcinoma Endometrial Hyperplasia Endometrial Adenocarcinoma 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Alex Ferenczy
    • 1
    • 2
  • Christine Bergeron
    • 1
    • 2
  1. 1.Department of PathologyMcGill University and The Sir Mortimer B. Davis Jewish General HospitalMontrealCanada
  2. 2.Department of Obstetrics and GynecologyMcGill University and The Sir Mortimer B. Davis Jewish General HospitalMontrealCanada

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