Chiasmatic-Hypothalamic Tumors in Children

  • Luis A. Rodriguez
  • Michael S. B. Edwards
Part of the Contemporary Perspectives in Neurosurgery book series (COPENEU)


Gliomas of the optic pathway are usually reported as a single entity. Martin and Cushing1 found 0.84% of 823 tumors in all age groups to be gliomas of the optic pathways. They noted difficulty in determining the site of origin of these tumors, since they often extend from the retro-orbital optic nerve and chiasm into the hypothalamus and vice versa. In children and adolescents the incidence (3% of 700 brain tumors)2 of optic pathway gliomas is higher than in adults.


Diabetes Insipidus Anaplastic Astrocytoma Partial Resection Optic Pathway Precocious Puberty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Martin P, Cushing H: Primary gliomas of the chiasm and optic nerves in their intracranial portion. Arch Ophthalmol 1923; 52: 209–241.Google Scholar
  2. 2.
    Koos WT, Miller MH: Intracranial Tumors of Infants and Children. London, Churchill, 1971, pp 172–188.Google Scholar
  3. 3.
    Matson DD: Neurosurgery of Infancy and Childhood, ed 2. Springfield IL, Thomas, 1969.Google Scholar
  4. 4.
    Dosoretz DE, Blitzer PH, Wang CC, et al: Management of glioma of the optic nerve and/or chiasm. An analysis of 20 cases. Cancer 1980; 45: 1467–1471.PubMedCrossRefGoogle Scholar
  5. 5.
    Tenny RT, Laws ER, Younge BR, et al: The neurosurgical management of optic glioma. Results in 104 patients. J Neurosurg 1982; 57: 452–458.PubMedCrossRefGoogle Scholar
  6. 6.
    Wong JYC, Uhl V, Wara WM, et al: Optic gliomas. A reanalysis of the University of California, San Francisco experience. Cancer 1987; 60: 1847–1855.PubMedCrossRefGoogle Scholar
  7. 7.
    Russell A: A diencephalic syndrome of emaciation in infancy and childhood. Arch Dis Child 1951; 26: 274–280.Google Scholar
  8. 8.
    Borit A, Richardson EP: The biological and clinical behaviour of pilocytic astrocytomas of the optic pathways. Brain 1982; 105: 161–187.PubMedCrossRefGoogle Scholar
  9. 9.
    Roberson C, Till K: Hypothalamic gliomas in children. J Neurol Neurosurg Psychiatry 1974; 37: 1047–1052.CrossRefGoogle Scholar
  10. 10.
    Montgomery AB, Griffin T, Parker RG, et al: Optic nerve glioma: the role of radiation therapy. Cancer 1977; 40: 2079–2080.PubMedCrossRefGoogle Scholar
  11. 11.
    Taveras JM, Mount LA, Wood EH: The value of radiation therapy in the management of glioma of the optic nerves and chiasm. Radiology 1956; 66: 518–528.PubMedGoogle Scholar
  12. 12.
    Chutorian AM, Schwartz JF, Evans RA, et al: Optic gliomas in children. Neurology 1964; 14: 83–95.PubMedCrossRefGoogle Scholar
  13. 13.
    Rush JA, Younge BR, Campbell RJ, et al: Optic glioma. Long term follow-up of 85 histopathologically verified cases. Ophthalmology 1982; 89: 1213–1219.PubMedGoogle Scholar
  14. 14.
    Imes RK, Hoyt WF: Childhood chaismal gliomas: update on the fate of patients in the 1969 San Francisco study. Br J Ophthalmol 1986; 70: 179–182.PubMedCrossRefGoogle Scholar
  15. 15.
    Rosenstock JG, Packer RJ, Bilaniuk L, et al: Chiasmatic optic glioma treated with chemotherapy. A preliminary report. J Neurosurg 1985; 63: 862–866.PubMedCrossRefGoogle Scholar
  16. 16.
    Hoyt WF, Baghdassarian SB: Optic glioma of childhood. Natural history and rationale for conservative management. Br J Ophthalmol 1969; 53: 793–798.PubMedCrossRefGoogle Scholar
  17. 17.
    Packer RJ, Savino PJ, Bilaniuk LT, et al.: Chiasmatic gliomas of childhood. A reappraisal of natural history and effectiveness of cranial irradiation. Child’s Brain 1983; 10: 393–403.PubMedGoogle Scholar
  18. 18.
    DeSousa AL, Kalsbeck JE, Mealey J Jr, et al: Optic chiasmatic glioma in children. Am J Ophthalmol 1979; 87: 376–381.PubMedGoogle Scholar
  19. 19.
    Marshall D: Glioma of the optic nerve as a manifestation of von Recklinghausen’s disease. Am J Ophthalmol 1954; 37: 15–36.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Luis A. Rodriguez
    • 1
  • Michael S. B. Edwards
    • 1
  1. 1.Department of NeurosurgeryUniversity of California at San FranciscoSan FranciscoUSA

Personalised recommendations