Diencephalic Neurology

Hypothalamic Obesity and Emaciation
  • Gary M. Abrams
Part of the Contemporary Perspectives in Neurosurgery book series (COPENEU)


Advances in our knowledge of the mechanism of neurosecretion have provided new insight into neurochemical control of the pituitary gland. Neurosecretory neurons, predominantly in the medial basal hypothalamus, have been shown to produce releas­ing and inhibitory factors that are delivered to the pituitary gland via the portal vas­culature of the median eminence.1 These neurohormones have generally been charac­terized as oligopeptides or biogenic amines While most experimental data have been obtained in the rodent, and species differences do exist, the location and function of these neurohormones in primates is analogous to those in other mammals. Neurons of the hypothalamus project to a wide variety of extrahypothalamic sites. “Hypothalamic hormones” have also been localized in neurons in many regions of the central nervous system that are not generally associated with endocrine or secretory functions. The extrahypothalamic function of neurohormones is uncertain, but they would appear to play an important role in autonomic, visceral, and sensory regulation.


Anorexia Nervosa Pituitary Gland Median Eminence Islet Cell Tumor Medial Basal Hypothalamus 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Gary M. Abrams
    • 1
  1. 1.College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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