The relationship of poxviruses and the immune system is the oldest recorded association of its kind in medical literature. It began in 1798, when Jenner showed that immunity to one orthopoxvirus, cowpox, prevented the develop ment of disease due to a related orthopoxvirus, variola, or smallpox. Initially, the use of cowpox inoculation to prevent smallpox was not universally successful. Other less benign vaccination techniques, including attenuated smallpox, were used. Finally, the introduction of vaccinia virus vaccination for smallpox and its widespread use resulted in the elimination of variola virus from the list of human scourges a decade ago.
KeywordsSpleen Cell Vaccinia Virus Infected Rabbit Variola Virus Immunologic Dysfunction
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