Immunosuppression by Bovine Herpesvirus 1 and Other Selected Herpesviruses

  • Lorne A. Babiuk
  • M. J. P. Lawman
  • P. Griebel
Part of the Infectious agents and pathogenesis book series (IAPA)


Viruses can cause immunosuppression by a variety of mechanisms. Immu nosuppression can occur as a result of direct or indirect effects of the virus on various leukocyte populations(1–5) In the case of direct effects, viruses may infect and destroy the specific leukocytes involved in the development and expression of immunity. In addition, viral components that can be released into the extracellular environment may interact directly with specific cells and affect either accessory or effector cell functions.(6) Indirect effects can be produced by the release of mediators, such as hormones, complement, or prostaglandins. (7–9) Inhibition of mediator release following viral infection can also reduce cellular reactivity and subsequent development of immunity.(10–12) In some instances, immunosuppression is confined to the specific antigen(s) causing the suppression, whereas in other instances there is generalized immunosuppression to a wide variety of antigens.(3,13) Thus, it is clearly evident that the phenomenon of virus-induced immunosuppression can occur via a wide variety of different pathways, and in many cases a combination of factors aDDears to act in concert.


Respiratory Syncytial Virus Alveolar Macrophage Pseudorabies Virus Bovine Herpesvirus Equine Herpesvirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Lorne A. Babiuk
    • 1
  • M. J. P. Lawman
    • 1
  • P. Griebel
    • 1
  1. 1.Department of Veterinary Microbiology and Veterinary Infectious Disease OrganizationUniversity of SaskatchewanSaskatoonCanada

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