Epstein—Barr Virus-Induced Immune Deficiency

  • David T. Purtilo
  • Helen L. Grierson
Part of the Infectious agents and pathogenesis book series (IAPA)


Epstein—Barr virus (EBV) is an ubiquitous herpesvirus infecting human beings and primates, exclusively. Lymphocytic proliferation associated with EBV in fection, the normal immune responses controlling the virus, the transient anergy occurring during acute infectious mononucleosis (IM), and the acquired progressive immune defects occurring in males with the X-linked lymphoproliferative syndrome (XLP) are described in this chapter. The results of a decade of investigation of the Duncan family are summarized to illustrate mechanisms of virus-induced immune suppression.


Malignant Lymphoma Burkitt Lymphoma Latent Membrane Protein Infectious Mononucleosis Primary ImmunodefiCIency DISease 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David T. Purtilo
    • 1
  • Helen L. Grierson
    • 1
  1. 1.Departments of Pathology and Microbiology, and Pediatrics, and the Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical CenterOmahaUSA

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