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Adenoviruses

  • Warren A. Andiman
  • Marie F. Robert
Part of the Infectious agents and pathogenesis book series (IAPA)

Abstract

The adenoviruses of humans, of which there are now 41 serotypes, are naked icosahedrons, 70–90 nm in diameter, and contain a genome composed of linear double-stranded DNA. They are associated with a wide spectrum of diseases (Table I) and they have been isolated from virtually all organs, but they are primarily regarded as common pathogens of the respiratory tract and eye. Most individuals become infected early in life with at least several sero types. To a certain extent, the kinds of adenovirus-associated diseases to which people become susceptible change as they grow older; each of these illnesses is caused by a limited number of serotypes. With rare exceptions, adenovirus infections are short-lived and self-limited.

Keywords

Acquire Immune Deficiency Syndrome Adenovirus Infection Adenovirus Type Human Adenovirus Severe Combine Immunodeficiency Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Boudin, M.-L., and P. Boulanger, Antibody triggered dissociation of adenovirus penton capsomer, Virology 113:781–786 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    Gerna, G., E. Cattaneo, M. Grazia Revello, M. Battaglia, and G. Achilli, Antibody to human adenovirus early antigens during acute adenovirus infections, Infect. Immun. 32:778–787 (1981).PubMedGoogle Scholar
  3. 3.
    McCormick, D. P., R. P. Wenzel, J. A. Davies, and W. E. Beam, Nasal secretion protein responses in patients with wild-type adenovirus disease, Infect. Immun. 6:282–288 (1972).PubMedGoogle Scholar
  4. 4.
    Gupta, A. K., and G. S. Sarin, Serum and tear immunoglobulin levels in acute ade novirus conjunctivitis, Br. J. Ophthalmol. 67:195–198 (1983).PubMedCrossRefGoogle Scholar
  5. 5.
    Top, F. H., Jr., Control of adenovirus acute respiratory disease in U.S. Army trainees, Yale J. Biol. Med. 48:185–195 (1975).PubMedGoogle Scholar
  6. 6.
    Top, F. H., R. A. Grossman, P. J. Bartelloni, H. E. Segal, B. A. Dudding, P. K. Russell, and E. L. Buescher, Immunization with live types 7 and 4 adenovirus vaccine. I. Safety, infectivity, antigenicity and potency of adenovirus type 7 vaccine in humans, J. Infect. Dis. 124:148–160 (1971).PubMedCrossRefGoogle Scholar
  7. 7.
    Smith, T. J., E. L. Buescher, F. H. Top, W. A. Altemeier, and J. M. McCown, Experi mental respiratory infection with the type 4 adenovirus vaccine in volunteers: Clinical and immunological responses, J. Infect. Dis. 122:239–248 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    Schwartz, A. R., Y. Togo, and R. B. Hornick, Clinical evaluation of live oral types 1,2,5 adenovirus vaccines, Am. Rev. Respir. Dis. 109:233–238 (1974).PubMedGoogle Scholar
  9. 9.
    Kasel, J. A., R. H. Alford, J. R. Lehrich, P. A. Banks, M. Huber, and V. Knight, Adenovirus soluble antigens for human immunization: A progress report, Am. Rev. Respir. Dis. 94:170–174 (1966).Google Scholar
  10. 10.
    Jen, K.-F., Y. Tai, Y.-C. Lin, and H.-Y. Wang, The role of adenovirus in the etiology of infantile pneumonia and pneumonia complicating measles, Chinese Med. J. 81:141–146 (1962).PubMedGoogle Scholar
  11. 11.
    Schonland, M., M. L. Strong, and A. Wesley, Fatal adenovirus pneumonia: Clinical and pathological features, S. Afr. Med. J. 50:1748–1751 (1976).PubMedGoogle Scholar
  12. 12.
    Lang, W. R., C. W. Howden, J. Laws, and J. F. Burton, Bronchopneumonia with serious sequelae in children with evidence of adenovirus type 21 infection, Br. Med. J. 1:73–79 (1969).PubMedCrossRefGoogle Scholar
  13. 13.
    Keller, E. W., R. H. Rubin, P. H. Black, and M. Hirsch, Isolation of adenovirus type 34 from a renal transplant recipient with interstitial pneumonia, Transplantation 23:188– 190 (1977).PubMedCrossRefGoogle Scholar
  14. 14.
    Stalder, H., J. C. Hierholzer, and M. Oxmar, New human adenovirus (candidate adenovirus type 35) causing fatal disseminated infection in a renal transplant patient,/. Clin. Microbiol. 6:257–265 (1977).PubMedGoogle Scholar
  15. 15.
    dejong, P. J., G. Valderrama, I. Spigland, and M. S. Horwitz, Adenovirus isolates from urine of patients with acquired immunodeficiency syndrome, Lancet 1:1293–1296 (1983).CrossRefGoogle Scholar
  16. 16.
    Wigger, H. J. and W. A. Blanc, Fatal hepatitis and necrosis in adenovirus infection with thymic alymphoplasia, N. Engl. J. Med. 275:870–874 (1966).PubMedCrossRefGoogle Scholar
  17. 17.
    Dudding, B. A., S. C. Wagner, J. A. Zeller, J. T. Gmelich, E. R. French, and F. H. Top, Fatal pneumonia associated with adenovirus type 7 in three military trainees, N. Engl. J. Med. 286:1289–1292 (1972).PubMedCrossRefGoogle Scholar
  18. 18.
    Strieder, D. J., and G. Nash, Weekly clinicopathological exercises. Case 12–1975, N. Engl. J. Med. 292:634–640 (1975).CrossRefGoogle Scholar
  19. 19.
    Varsano, I., T. M. Schonfeld, Y. Matoth, B. Shohat, T. Englander, V. Rotter, and N. Trainin, Severe disseminated adenovirus infection successfully treated with a thymic humoral factor, Acta Paediatr. Scand. 66:329–331 (1977).PubMedCrossRefGoogle Scholar
  20. 20.
    Horvath, J., G. Kolesar, J. P. Ugryumov, P. Das, I. Nasz, Z. F. Barinsky, G. Simon, and J. Ongradi, Effect of adenovirus infection on human peripheral lymphocytes, Acta Microbiol. Hung. 30:203–209 (1983).PubMedGoogle Scholar
  21. 21.
    Huang, S.-W., D. B. Lattos, D. B. Nelson, K. Reeb, and R. Hong, Antibody-associated lymphotoxin in acute infection, J. Clin. Invest. 52:1033–1040 (1973).PubMedCrossRefGoogle Scholar
  22. 22.
    Huang, S.-W. and R. Hong, Immunologic deficiences during viral infection. (Letter.), N. Engl. J. Med. 292:1296 (1975).PubMedGoogle Scholar
  23. 23.
    Berencsi, K., M. Bakay, and I. Beladi, The role of macrophages in adenovirus-induced immunosuppression in mice, Acta Virol. 29:61–65 (1985).PubMedGoogle Scholar
  24. 24.
    Berencsi, K., M. Bakay, and P. Kovacs, Effect of human adenovirus type 6 on the primary immune response in mice, Acta Virol. 26:340–345 (1982).PubMedGoogle Scholar
  25. 25.
    Cook, S. L., and A. M. Lewis, Differential NK and macrophage killing of hamster cells infected with nononcogenic or oncogenic adenovirus, Science 224:612–615 (1984).PubMedCrossRefGoogle Scholar
  26. 26.
    Gallimore, P. H. and C. Paraskeva, A study to determine the reasons for differences in the tumorigenicity of rat cell lines transformed by adenovirus 2 and adenovirus 12, Cold Spring Harbor Symp. Quant. Biol 44:703–713 (1979).CrossRefGoogle Scholar
  27. 27.
    Mandi, Y., M. Bakay, and I. Beladi, Effect of human adenoviruses on antibody-depen dent cellular cytotoxicity (ADCC) in chickens, Cell. Immunol. 69:395–400 (1982).PubMedCrossRefGoogle Scholar
  28. 28.
    Lysov, V. V., O. A. Aksenon, V. I. Rudenko, S. A. Moshkin, T. I. Huyrlova, A. A. Smorodintsev, and A. A. Selivanon, Interference activity and sensitivity to interferon of original and cold strains of adenovirus types 1 and 2, Acta Virol. (Praha) 15:387–392 (1971).Google Scholar
  29. 29.
    Pusztai, R., K. Berendsi, I. Beladi, and E. Szabo, Relationship between interferon production and transformation of chick cells infected with human adenovirus type 12, in: Interferon and Interferon Inducers (I. Foldes and M. Talas, eds.), pp. 100–108, Research Group of the Hungarian Academy of Sciences, Budapest (1976).Google Scholar
  30. 30.
    Langford, M. P., A. L. Villarreal, and G. J. Stanton, Antibody and interferon act syn-ergistically to inhibit enterovirus, adenovirus, and herpes simplex virus infection, Infect. Immun. 41:214–218 (1983).PubMedGoogle Scholar
  31. 31.
    Beladi, I., and R. Pusztai, Interferon-like substance produced in chick fibroblast cells inoculated with human adenovirus, Z. Naturforsch. 226:165–169 (1967).Google Scholar
  32. 32.
    Ho, M., and K. Kohler, Studies on human adenoviruses as inducers of interferon in chick cells, Arch. Gesamte Virusforsch. 22:69–78 (1967).PubMedCrossRefGoogle Scholar
  33. 33.
    Pusztai, R., I. Beladi, M. Bakay, and I. Mucsi, Effect of ultraviolet irradiation and heating on the interferon inducing capacity of human adenoviruses, J. Gen. Virol 4:169–176 (1969).PubMedCrossRefGoogle Scholar
  34. 34.
    Toth, M., M. Bakay, B. Torodi, S. Toth, R. Pusztai, and I. Beladi, Different interferon-inducing ability of human adenovirus types in chick embryo cells, Acta Virol. (Praha) 27:337–345 (1983).Google Scholar
  35. 35.
    Ho, M., Animal viruses and interferon formation, in: Interferon and Interferon Inducers (N. B. Finter ed.), pp. 29–44, North-Holland, Amsterdam (1973).Google Scholar
  36. 36.
    Romano, A., M. Revel, D. Guarari-Rotman, M. Blumenthal, and R. Stein, Use of human fìbroblast-derived (beta) interferon in the treatment of epidemic adenovirus keratoconjunctivitis, J. Interferon Res. 1:95–100 (1980).PubMedCrossRefGoogle Scholar
  37. 37.
    Romano, A., E. Ladizensky, D. Guarari-Rothman, and M. Revel, Clinical effect of human fibroblast-derived (beta) interferon in treatment of adenovirus epidemic keratoconjunctivitis and its complications, Tex. Rep. Biol. Med. 41:559–565 (1981–1982).PubMedGoogle Scholar
  38. 38.
    Beladi, I., R. Pusztai, I. Mucsi, M. Bakay, and G. Bajszar, Effect of human adenoviruses on the response of chickens to sheep erythrocytes, Infect. Immun. 7:22–28 (1973).PubMedGoogle Scholar
  39. 39.
    Hamburg, V., O. Scherbakova, and G. Svet-Moldavsky, Suppression of antibody formation against Sendai Virus in SV40 and adenovirus 16 infected hamsters, Experientia 26:532–534 (1970).PubMedCrossRefGoogle Scholar
  40. 40.
    Friedman, H., and H. Goldner, Relationship between immunologic maturation and viral oncogenesis in hamsters,/. Natl. Cancer Inst. 44:809–817 (1970).PubMedGoogle Scholar
  41. 41.
    Strohl, W. A. and R. W. Schlesinger, Quantitative studies of natural and experimental adenovirus infections of human cells, Virology 26:208–220 (1965).PubMedCrossRefGoogle Scholar
  42. 42.
    Lambriex, M., and J. van der Veen, Comparison of replication of adenovirus type 2 and type 4 in human lymphocyte cultures, Infect Immun. 14:618–622 (1976).PubMedGoogle Scholar
  43. 43.
    Faucon, N., and C. Desgranges, Persistence of human adenovirus 5 in human cord blood lymphoblastoid cell lines transformed by Epstein-Barr virus, Infect. Immun. 29:1180–1184 (1980).PubMedGoogle Scholar
  44. 44.
    Faucon, N., Y. Chardonnet, M. C. Perrinet, and R. Sohier, Superinfection with adenovirus of Burkitt’s lymphoma cell lines, J. Natl. Cancer Inst. 53:305–307 (1974).PubMedGoogle Scholar
  45. 45.
    Andiman, W. A., R. I. Jacobson, and G. Tucker, Leukocyte-associated viremia with adenovirus type 2 in an infant with lower-respiratory tract disease, N. Engl. J. Med. 297:100–101 (1977).PubMedCrossRefGoogle Scholar
  46. 46.
    Andiman, W. A., and G. Miller, Persistent infection with adenovirus types 5 and 6 in lymphoid cells from humans and woolly monkeys, J. Infect. Dis. 145:83–88 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Warren A. Andiman
    • 1
  • Marie F. Robert
    • 1
    • 2
    • 3
  1. 1.Department of PediatricsYale University School of MedicineNew HavenUSA
  2. 2.Department of EpidemiologyYale University School of MedicineNew HavenUSA
  3. 3.Department of Public HealthYale University School of MedicineNew HavenUSA

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