Effect of Vesicular Stomatitis Virus Infection on the Development and Regulation of Cell-Mediated and Humoral Immune Responses
  • Man-Sun Sy
  • Robert Finberg
Part of the Infectious agents and pathogenesis book series (IAPA)


Vesicular stomatitis virus (VSV) belongs to the family of rhabdoviruses. This group of viruses includes VSV, rabies virus, Marburg virus, and several other viruses that replicate in anthropoids as well as in other mammals.(1,2) The natural hosts of these viruses are listed in Table I. One of the major mor phologic features of this group of viruses is their bullet-shaped virion. These bullet-shaped rods are cylinders approximately 170 nm in length and 70 nm in diameter. Each particle consists of a nucleoprotein (RNA) core helically wound around a central axial hollow. This is enclosed in an envelope consisting of a lipid bilayer and associated structural proteins. In the VSV group, there are distinct strains, including Indiana, New Jersey, Brazil, Argentina, Cocal, Piry, and Chandipura. All the strains except Piry and Chandipura share some common antigens; those two strains appear to be totally unrelated antigenically to others.(3) According to the nomenclature of Wagner et al.,(4) proteins of the Indiana serotype are designated L, G, N, NS, and M and have molecular weights of 190, 69, 50, 45, and 29 kDa, respectively.(5)


Spleen Cell Acquire Immune Deficiency Syndrome Rabies Virus Vesicular Stomatitis Virus Human Immune Deficiency Virus 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Man-Sun Sy
    • 1
  • Robert Finberg
    • 2
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA
  2. 2.Laboratory of Infectious DiseasesDana Farber Cancer InstituteBostonUSA

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