Reoviruses are members of Reoviridae, a family of double-stranded (ds) RNA viruses that infect vertebrates, insects, arthropods, and plants.(1) Mammalian reoviruses are icosahedral virions, 76 nm in diameter, with a double capsid consisting of a central core of 52 nm surrounded by an outer protein shell. The viral genome consists of 10 fragments of ds RNA with molecular weight rang ing from 0.5 to 2.7 × 106 kDa. There are three large segments (L1, L2, L3), three medium segments (M1, M2, M3), and four small segments (S1, S2, S3, S4). Viral replication occurs in the cytoplasm of infected cells, in which each genome fragment, corresponding to a single gene, is transcribed by a viral transcriptase into a messenger RNA (mRNA) molecule and subsequently translated into a primary polypeptide. Viral assembly takes place within cytoplasmic inclusions, and infected cells are ultimately destroyed with release of the progeny virus.
KeywordsNewborn Mouse Viral Pathogenesis Viral Hemagglutinin Icosahedral Virion Reovirus Type
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