Monoclonal Antibodies and Drug Targeting in Cancer

  • Karol Sikora
Part of the NATO ASI Series book series (NSSA, volume 155)


There has been remarkable little progress in the management of patients with common solid tumors over the last 20 years. Surgery and radiotherapy have reached a peak of therapeutic effectiveness whilst the benefits of systemic treatment using drugs or hormones have reached a therapeutic plateau in tumors such as those of the breast, lung and colon. The reason for this is the lack of selectivity of currently available systemic agents. The closeness of the biochemical properties of tumor cells to their normal counterparts has made the successful development of anti-cancer agents an elusive quest.


Chronic Lymphocytic Leukaemia Acute Lymphoblastic Leukaemia Human Monoclonal Antibody Tumor Cell Surface Melanoma Associate Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barratt, G. M., Ryman, B., Begent, R. H., and Bagshawe, K. D., 1983, Improved radioimmunodection of tumors using liposome entrapped antibody. Biochem Biophys.acta.,762:154.PubMedCrossRefGoogle Scholar
  2. Box, P. C., Berenstein, E. H., and Siraganian, R. P., 1982, Techniques for enhancing the yield of antigen specific hybridomas, in: M.S. Mitchell and H.F. Oettgen, eds, “Hybridomas and Cancer Diagnosis and Treatment,” Raven Press, New York.Google Scholar
  3. Brown, J. P., Woodbury, R. G., Hart C. E., Hellstrom, I., and Hellstrom, K. E., 1981, Quantitative analysis of melanoma associated antigen p. 97 in normal and neoplastic tissues, Proc.Nat.Acad.Sci.USA. 78:539.PubMedCrossRefGoogle Scholar
  4. Chan, S., Evan, G., Ritson, A., Watson, J., and Sikora, K., 1986, Radio-immunolocalization of the c-myc oncogene product in patients with cancer, Br.J.Cancer., 54:761.PubMedCrossRefGoogle Scholar
  5. Curry, G. A., 1972, Eighty years of immunotherapy: A review of immunological methods used for the treatment of human cancer, Br.J.Cancer, 26:141.CrossRefGoogle Scholar
  6. Dilman, R. O., Collins, H., and Royston, I., 1982, T101 monoclonal antibody therapy in chronic lymphocytic leukaemia, in: M.S. Mitchell and J.F. Oettgen, eds, Hybridomas in cancer diagnosis and treatment, Raven Press, New York.Google Scholar
  7. Dippold, W. G., Lloyd, K. O., Lucy, T. C. and Old, L. J., 1980, Cell surface antigens of human malignant melanoma. Proc.Nat.Acad.Sci.USA, 77:6114.PubMedCrossRefGoogle Scholar
  8. Embleton, M. J., Flannery, G. R., and Baldwin, R. W., 1982, The effects of monoclonal antibody directed immunotoxins and immuno-modulators on cultured osteogenic sarcoma cells, Br.J.Cancer, 46:477.Google Scholar
  9. Finan, P. J., Ritson, A., and Sikora, K., 1986, Monoclonal antibody immuno-scintigraphy for the detection of primary colorectal cancers: a prospective study. Br.J.Surgery, 73:177.CrossRefGoogle Scholar
  10. Hurlyn, D., Steplewski, Z., and Kaprowski, H., 1979, Monoclonal antibodies in cell mediated cytotoxicity against human melanoma and colorectal carcinoma. Eur.J.Immunol. 9:657.CrossRefGoogle Scholar
  11. Khaw, B. A., Gold, H. K., Yasuda, T., and Haber, E., 1986, Scintigraphic quantification of myocardial necrosis in patients after intravenous injection of myosin-specific antibody, Circulation, 74;501.PubMedCrossRefGoogle Scholar
  12. Mach, J. P., Buchegger and Karrel, S., 1981, Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photo-scanning and tomoscinti-scanning, Immunol.Today., 2:239.CrossRefGoogle Scholar
  13. Miller, R. A., and Levy R., 1981, Response of cutaneous T-cell lymphoma to therapy with hybridoma monoclonal antibody, Lancet, 2:226.PubMedCrossRefGoogle Scholar
  14. Miller, R. A., and Levy, R., 1981, In-vivo effects of murine hybridoma antibody in a patient with T-cell leukaemia, Blood, 58:78.PubMedGoogle Scholar
  15. Miller, R. A., Muloney, D. G., and Levy R., 1982, Treatment of B-cell lymphoma with monoclonal anti-idiotype antibodies, New Eng.J.Med., 306:517.PubMedCrossRefGoogle Scholar
  16. Nadler, M., Stashenko, P., Hardy, R., and Schlossman, S. F., 1980, Serotherapy of a patient with a monoclonal antibody directed against a humanous, lymphoma associated antigen, Cancer Res., 40:3147.PubMedGoogle Scholar
  17. Phillips, J., Alderson, T., Sikora, K., and Watson, J. V., 1983, Localization of malignant glioma by radiolabelled monoclonal antibody, Neurol, Neurosurg,Psych., 46:388.CrossRefGoogle Scholar
  18. Ritz, J., Clavell, L. A., and Schlossman, S. F., 1981, Serotherapy of acute lymphoblastic leukaemia with a monoclonal antibody, Blood, 58:361.Google Scholar
  19. Roberts, S, Cheetham, J. C., and Reece, A. R., 1987, Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering, Nature, 328:731.PubMedCrossRefGoogle Scholar
  20. Ross, B., Langman, R., Torwbridge, I., and Becker, R., 1983, Monoclonal Antibodies and Cancer, Academic Press, New York.Google Scholar
  21. Sikora, K., and Wright, R., 1981, Human monoclonal antibodies to lung cancer antigens, Br.J.Cancer, 43:696.PubMedCrossRefGoogle Scholar
  22. Sikora, K., Alderson, T., and Ellis, J., 1982, Human hybrodomas from patients with malignant disease, Br.J.Cancer, 46:477.Google Scholar
  23. Sikora, K, Finan, T., Lennox, E., and Smedley, H., 1983, The selection of monoclonal antibodies for the localization of colorectal cancer, Br.J.Cancer, 47:253.PubMedCrossRefGoogle Scholar
  24. Sikora, K., Evan, G., Stewart, J., and Watson, J., 1985, Detection of the c-myc oncogene product in testicular cancer, Br.J.Cancer, 52:171.PubMedCrossRefGoogle Scholar
  25. Smedley, H., Finan, P., and Sikora, K., 1983, Localization of metastatic carcinoma by radiolabelled monoclonal antibody, Br.J.Cancer, 286:262.Google Scholar
  26. Sobol, R. E., Dillman, R. O., and Royston, I., 1982, Phase 1 evaluation of immune monoclonal anti-melanoma antibody in man, in: M.S. Mitchell and H.F. Oettgen, eds., “Hybridomas in Cancer Diagnosis and Treatment,” Raven Press, New York.Google Scholar
  27. Stewart, J., Evan, G., Watson, J., and Sikora, K., 1986, Detection of the c-myc oncogene product in colonic polyps and carcinomas, Br.J.Cancer, 51:1.CrossRefGoogle Scholar
  28. Thorpe, P. E., Edwards, D. C., and Ross, W. C. J., 1982, Monoclonal antibody toxin conjugates, in: A.J. McMichael and J.W. Fabre, eds, “Monoclonal Antibodies in Clinical Medicine,” London, Academic Press.Google Scholar
  29. Watson, J. V., Evan, G. I., and Sikora, K., 1985, Quantitation of oncogene products in archival pathology material, J.Immunol.Methods, 83:170.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Karol Sikora
    • 1
  1. 1.Department of Clinical OncologyHammersmith HospitalLondonUK

Personalised recommendations