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Free Radicals in Health and Disease: Implications for Drug Delivery and Targeting

  • Catherine Rice-Evans
Part of the NATO ASI Series book series (NSSA, volume 155)

Abstract

Free radicals are essential to many normal biological processes, e.g. as intermediates in enzyme-catalysed reactions, in prostaglandin synthesis, in tissue response to invading micro-organisms, and yet can be highly destructive if not tightly controlled. Radicals species have been implicated in many diseased states (Table 1) (Halliwell, 1987). The question as to whether free radical reactions are a cause of tissue damage or an accompaniment to or a consequence of such injury is by no means clear as yet in many instances. However, what is clear is that diseased or damaged tissues undergo radical reactions more readily than normal tissues (Halliwell & Gutteridge, 1985a), thus exacerbating the primary lesion.

Keywords

Lipid Peroxidation Hyaluronic Acid Respiratory Burst Lipid Hydroperoxide Peroxy Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Catherine Rice-Evans
    • 1
  1. 1.Department of BiochemistryRoyal Free Hospital School of MedicineLondonUK

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