The Hepatic Receptor for Asialoglycoproteins: Search for a Function

  • J. Clifford Steer
  • Peretz Weiss
  • Peter J. Wirth
  • Gilbert Ashwell
Part of the NATO ASI Series book series (NSSA, volume 155)

Abstract

During the last half decade increased interest has been directed towards an understanding of the mechanism whereby cell surface receptor expression is modulated. A number of receptors have become available for such examination, including the glucocorticoid receptor of hepatoma cells (Okret et al, 1986), the transferrin receptor in K562 cells (Rouault et al, 1985; Mattia et al, 1984), the EGF receptor in KB cells (Fearn and King, 1985), as well as the LDL receptor in rat hepatocytes (Ma et al, 1986; Larkin et al, 1985). In short, the expression of cell surface receptors has been shown to reflect regulatory mechanisms enabling the cell to adapt itself to changing metabolic priorities.

Keywords

Hepatitis Manifold Electrophoresis Half Life Glucocorticoid 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. Clifford Steer
    • 1
  • Peretz Weiss
    • 1
  • Peter J. Wirth
    • 2
  • Gilbert Ashwell
    • 1
  1. 1.Laboratory of Biochemistry and MetabolismNational Institute of Diabetes, Digestive and Kidney DiseasesBethesdaUSA
  2. 2.Laboratory of Experimental Carcinogenesis, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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