Targeting Using Physical Approaches and Particulate Drug Carriers: Interaction with the Biological Milieu
In many disease conditions, selectivity in drug delivery would be of considerable advantage. Cancer chemotherapy is the often quoted example where antitumor drugs can destroy the target (tumor cells) but can also have an undesirable effect on non-target cells. This chapter will focus on the possibilities and pitfalls of attempting drug targeting using physical approaches such as colloidal particles in the form of microspheres, liposomes or emulsions. Firstly, the feasibility of targeting needs to be considered. In some attempts at so called ‘Drug targeting’, it can be overlooked that the target may not be well defined. Certainly it is important to decide at a very early stage what one is aiming at, and whether the target is discrete and accessible. In addition, some differences between target and non-target must be discernible.
KeywordsKupffer Cell Colloidal Particle Reticuloendothelial System Physical Approach Vascular Compartment
Unable to display preview. Download preview PDF.
- Bonté, F., and Juliano, R. L., Interaction of liposomes with serum proteins, Chem.Phys.Lip., 40:359.Google Scholar
- Croft, S. L., 1986, Liposomes in the treatment of parasitic disease, Parm.Internat., 7:229.Google Scholar
- Davis, S. S., Douglas, S. J, Ilium, L., Jones, P. D. E., Mak, E., and Muller, R., 1986a, Passive and active delivery of colloidal carriers and the role of surface modifications, in: “Targeting of Drugs with Synthetic Systems,” G. Gregoriadis, J. Senior, and G. Poste, eds., Plenum Press, New York.Google Scholar
- Davis, S. S., and Ilium, L., 1986, Colloidal delivery systems: Opportunities and challenges, in: “Site Specific Delivery,” E. Tomlinson, and S. S. Davis, eds., Wiley, Chichester.Google Scholar
- Davis, S. S., Washington, C., West, P., Ilium, L., Liversidge, G., Sternson, L., and Kirsh, R., 1987, Lipid emulsions as drug delivery systems, Annal.New York Acad.Sci., in press.Google Scholar
- Ilium, L., Jones, P. D. E., Baldwin, R. W., and Davis, S. S., 1984, Tissue distribution of poly(hexyl-2-cyanacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts, J.Pharmacol.Exper.Therapeut., 230:733.Google Scholar
- Juliano, R. L., 1983, Interactions of proteins and drugs with liposomes, in: “Liposomes,” M. Ostro, ed., Marcel Dekker, New York.Google Scholar
- Poste, G., 1984, Drug Targeting in Cancer Chemotherapy in: “Receptor-mediated Targeting of Drugs,” G. Gregoriadis, G. Poste, J. Senior, and A. Trouet, eds., Plenum Press, New York.Google Scholar
- Poznansky, M. S., and Juliano, R. L., 1984, Biological approaches to the controlled delivery of drugs: a critical review, Pharmaco1. Rev., 36:277.Google Scholar
- Scherphof, G., Damen, J., and Hoekstra, P., 1981, Interactions of liposomes with plasma proteins and components of the immune system in: “Liposomes from Physical Structure to Therapeutic Application,” C. G. Knight, ed., Elsevier-North Holland, Amsterdam.Google Scholar