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Targeting Using Physical Approaches and Particulate Drug Carriers: Interaction with the Biological Milieu

  • S. S. Davis
  • Lisbeth Illum
Part of the NATO ASI Series book series (NSSA, volume 155)

Abstract

In many disease conditions, selectivity in drug delivery would be of considerable advantage. Cancer chemotherapy is the often quoted example where antitumor drugs can destroy the target (tumor cells) but can also have an undesirable effect on non-target cells. This chapter will focus on the possibilities and pitfalls of attempting drug targeting using physical approaches such as colloidal particles in the form of microspheres, liposomes or emulsions. Firstly, the feasibility of targeting needs to be considered. In some attempts at so called ‘Drug targeting’, it can be overlooked that the target may not be well defined. Certainly it is important to decide at a very early stage what one is aiming at, and whether the target is discrete and accessible. In addition, some differences between target and non-target must be discernible.

Keywords

Kupffer Cell Colloidal Particle Reticuloendothelial System Physical Approach Vascular Compartment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. S. Davis
    • 1
  • Lisbeth Illum
    • 1
  1. 1.Department of PharmacyUniversity of NottinghamNottinghamUK

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