In Vivo Uptake and Processing of Liposomes by Parenchymal and Non-Parenchymal Liver Cells; Application to Immunotherapeutic Treatment of Hepatic Metastases

  • Gerrit L. Scherphof
  • Toss Daemen
  • Hans Derksen
  • George Lázár
  • Halbe H. Spanjer
  • Frits H. Roerdink
Part of the NATO ASI Series book series (NSSA, volume 155)


Many early investigations on the in vivo fate of intravenously injected liposomes have pointed to the liver as the major organ responsible for elimination from the circulatory system. For several years now we have made detailed studies on the participation of various cell types of the liver, mainly macrophages and hepatocytes, in the hepatic uptake and processing of liposomes, both in vivo and in vitro.


Bile Acid Kupffer Cell Hepatic Uptake Small Unilamellar Vesicle Liver Macrophage 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gerrit L. Scherphof
    • 1
  • Toss Daemen
    • 1
  • Hans Derksen
    • 1
  • George Lázár
    • 1
  • Halbe H. Spanjer
    • 1
  • Frits H. Roerdink
    • 1
  1. 1.Laboratory of Physiological Chemistry, Medical SchoolState University GroningenGroningenThe Netherlands

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