Advertisement

Serine Proteases Promote Human CFU-GM in Methylcellulose Culture Systems

  • Samuel Gross
  • Diana A. Worthington-White
  • Cheryl M. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)

Abstract

Amino acid sequences and three dimensional structural analysis of serine proteases show sequence homology in a group of compounds, which include thrombin, Cl’ esterase, urokinase, trypsin, plasminogen, snake venom, kallikrein, and the γ subunit of mouse submandibular gland nerve growth factor. Common to the structure of these enzymes are active sites consisting of aspartic acid, histidine and serine. The similarities between the various serine proteases are striking in a number of details, including cellular location, chemical structure, molecular weight and function.

Keywords

Serine Protease Snake Venom Mouse cDNA Clone Protease Inactivation Trypsin Specific Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Perris, A.D., and J.F. Whitfield. 1969. The mitogenic action of bradykinin on thymic lymphocytes and its dependence on calcium. Proc Soc. Exp. Biol. Med. 130: 1198–1201.PubMedGoogle Scholar
  2. 2.
    Rixon, R.H., J.F. Whitfield, and J. Bayliss. 1971. The stimulation of mitotic activity in the thymus and bone marrow of rats by kallikrein. Horm. Metab. Res. 3: 279–284.PubMedCrossRefGoogle Scholar
  3. 3.
    Schapira, M., C.F. Scott, L.A. Boxer, and R.W. Colman. 1983. Activation of human polymorphonuclear leukocytes by human plasma kallikrein. Adv. Exp. Med. Biol. 156: 747–753.PubMedGoogle Scholar
  4. 4.
    Mandel, P., J. Rodesch, and J.M. Mantz. 1973. The treatment of experimental radiation lesions by kallikrein. In: Kininogenases 1, ed. by G.L. Haberland and J.W. Rohen, pp. 171–188, Schattauer, Stuttgart, New York.Google Scholar
  5. 5.
    Kraut, J. 1977. Serine proteases: structure and mechanism of catalysis. Ann. Rev. Biochem. 46: 331–358.PubMedCrossRefGoogle Scholar
  6. 6.
    Stroud, R.M. 1974. A family of protein-cutting proteins. Sci Am 231: 74–88.PubMedCrossRefGoogle Scholar
  7. 7.
    Pisano, J.J. 1975. Chemistry and biology of the kallikrein-kinin system. In: Proteases and Biological Control, ed. Pisano, J.J, pp. 199–222, Cold Spring Harbor Laboratory.Google Scholar
  8. 8.
    Neurath, H., and K.A. Walsh. 1976. Role of proteolytic enzymes in biological regulation (a review). Proc. Natl. Acad. Sci. USA 73: 3825–3832.PubMedCrossRefGoogle Scholar
  9. 9.
    Levi-Montalcini, R., R.H. Angeletti, and P.U. Angelietti. 1972. The nerve growth factor. In: The Structure and Function of Nervous Tissue, ed. by G.H. Bourne, pp. 1–38, Academic Press, New York, London.Google Scholar
  10. 10.
    Bothwell, M.A., W.H. Wilson, and E.M. Shooter. 1979. The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland. J. Biol. Chem. 254: 7287–7294.PubMedGoogle Scholar
  11. 11.
    Habener, J.F., H.T. Change, and J.T. Potts. 1977. Enzymic processing Schacter, M., B. Maranda, and C. Moriwaki. 1978. Localization of kallikrein in the coagulation and submandibular glands of the guinea-pig. J. Histochem Cytochem 26: 318–321.CrossRefGoogle Scholar
  12. 12.
    Metealf, D. 1981. In: Tissue Growth Factors, ed. by R. Baserga, pp. 343–384, Springer, New York.CrossRefGoogle Scholar
  13. 13.
    Nicola, N.A., D. Metealf, M. Matsumoto, and G.R. Hohnson. 1983. Purification of a factor inducing differentiation in murine myelo- monocytic leukemia cells. Identification as granulocyte colony — stimulating factors. J. Biol. Chem. 258: 9017–9021.PubMedGoogle Scholar
  14. 14.
    Stanley, E.R., and P.M. Heard. 1977. Factors regulating macrophage production and growth. Purification and some properties of colony stimulating factors from medium conditioned by mouse L Cells. J. Biol. Chem. 252: 4305–4312.PubMedGoogle Scholar
  15. 15.
    Burgess, A.W., J. Camakaris, and D. Metcalf. 1977. Purification and properties of colony stimulating factors from mouse lung- conditioned medium. J. Biol. Chem. 252: 1998–2003.PubMedGoogle Scholar
  16. 16.
    Wokota, T., F. Lee, D. Rennich, et al. 1984. Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth factor activity in monkey cells. Proc. Natl. Acad. Sci. USA. 81: 1070–1074.CrossRefGoogle Scholar
  17. 17.
    Fung, M.C., A.J. Hapel, S. Ymer, et al. 1984. Molecular cloning of CDNA for murine interleukin-3. Nature 307: 233–237.PubMedCrossRefGoogle Scholar
  18. 18.
    Iscove, N.N., C.A. Roitsch, N. Williams, and L.J. Guilbert. 1982. Molecules stimulating early red cell, granulocyte, macrophage and megakaryocyte precursors in culture: Similarity in size, hydrophobicity, and charge. J. Cell Physiol. Suppl 1: 65–78.PubMedCrossRefGoogle Scholar
  19. 19.
    Bazill, C.W., M. Haynes, J. Garland, and T.M. Dexter. 1983. Qhar- acterization and partial purification of a hematopoietic growth factor in WEHI-3 cell conditioned medium. J. Biochem. 210: 747–759.Google Scholar
  20. 20.
    Wong, G.G., J.S. Witek, P.A. Temple, et al. 1985. Molecular cloning of the complimentary DNA and purification of the natural and recombinant proteins. Science 228: 810–815.PubMedCrossRefGoogle Scholar
  21. 21.
    Gough, N.M., J. Gough, D. Metcalf, et al. 1984. Molecular cloning of cDNA encoding a murine hematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature 303: 763–767.CrossRefGoogle Scholar
  22. 22.
    Kawasaki, E.S., M.B. Ladner, A.M. Wang, et al. 1985. Molecular cloning of a complimentary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science 230: 291–296.PubMedCrossRefGoogle Scholar
  23. 23.
    Iscove, N.N., J.S. Senn, J.E. Till, and E.A. McCulloch. 1971. Colony formation by normal and leukemic marrow cells in culture: Effects of conditioned medium from normal leukocytes. Blood 37: 1–5.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Samuel Gross
    • 1
  • Diana A. Worthington-White
    • 1
  • Cheryl M. Smith
    • 1
  1. 1.Department of PediatricsUniversity of Florida College of MedicineGainesvilleUSA

Personalised recommendations