Serine Proteases Promote Human CFU-GM in Methylcellulose Culture Systems

  • Samuel Gross
  • Diana A. Worthington-White
  • Cheryl M. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


Amino acid sequences and three dimensional structural analysis of serine proteases show sequence homology in a group of compounds, which include thrombin, Cl’ esterase, urokinase, trypsin, plasminogen, snake venom, kallikrein, and the γ subunit of mouse submandibular gland nerve growth factor. Common to the structure of these enzymes are active sites consisting of aspartic acid, histidine and serine. The similarities between the various serine proteases are striking in a number of details, including cellular location, chemical structure, molecular weight and function.


Serine Protease Snake Venom Mouse cDNA Clone Protease Inactivation Trypsin Specific Inhibitor 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Samuel Gross
    • 1
  • Diana A. Worthington-White
    • 1
  • Cheryl M. Smith
    • 1
  1. 1.Department of PediatricsUniversity of Florida College of MedicineGainesvilleUSA

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