Growth Factor-Related Mechanisms of Leukemogenesis
Acute myeloid leukemia is obviously a heterogeneous disease, different entities being distinguishable by differences in morphology, karyotype, disturbances in the expression of proto-oncogenes, clinical course etc. Some five years ago we made observations that indicated that one mechanism of leukemogenesis involved the malignant cell beginning to produce a hemopoietic growth factor that stimulated its own growth (Schrader and Crapper, 1983). Experiments in which cell-lines have been rendered leukemogenic by infection with retroviruses encoding hemopoietic growth factor genes, have formally confirmed the hypothesis that the inappropriate production of an autostimulatory growth factor by a hemopoietic cell that was immortal but not leukemogenic, could convert the cell to a transplantable leukemia (Lang, et al., 1985; Campbell, et al., 1987 and Nienhuis et al., this volume). Here, we summarize experiments that suggest that perturbations of growth factor production may be a relatively frequent feature of the leukemogenic process and that genetic techniques may allow pinpointing of diseases that involve this mechanism.
KeywordsAcute Myeloid Leukemia Monocytic Leukemia High Density Culture Hemopoietic Cell Exogenous Growth Factor
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