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Effect of Sustained Hypertransfusion on Rauscher Leukemia Virus-Variant A (RLV-A) Infection in BALB/c Mice

  • Gary Paul Leonardi
  • Michael Manthos
  • Joseph LoBue
  • Donald Orlic
  • Jyotirmay Mitra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)

Abstract

Infection of BALB/c mice with the RLV-A virus normally induces an erythropoietic dysplasia characterized by hepatosplenomegaly, erythroblastosis, erythroblastemia and severe anemia without reticulocytosis. Time to death varies between 20–30 weeks. Mice were inoculated with RLV-A after being hypertransfused with 75% packed red cells for 42 days which has been shown to eliminate erythropoiesis and modify the microenvironment to favor granulopoiesis. Following RLV-A inoculation, one group did not receive further transfusion (short-term) and another group continued with hypertransfusion weekly (long-term). The pathogenesis of RLV-A in the short-term group paralleled the characteristic RLV-A response. In the long-term group however, the characteristic RLV-A response was never observed. Instead, a granulocytic leukemia was developed. Continued hypertransfusion presumably after establishment of an altered microenvironment resulted in a completely different viral pathogenesis and the development of a transplantable myeloid leukemia.

Keywords

Viral Inoculation Granulocytic Leukemia Heparinized Syringe Viral Pathogenesis Donor Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gary Paul Leonardi
    • 1
    • 2
  • Michael Manthos
    • 1
    • 2
  • Joseph LoBue
    • 1
    • 2
  • Donald Orlic
    • 1
    • 2
  • Jyotirmay Mitra
    • 1
    • 2
  1. 1.Department of BiologyNew York UniversityNew YorkUSA
  2. 2.Department of AnatomyNew York Medical CollegeValhallaUSA

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