Homing of Hemopoietic Stem Cells to Hemopoietic Stroma

  • Cheryl L. Hardy
  • Mehdi Tavassoli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


The existing knowledge of the molecular mechanism that underlies the successful engraftment of hemopoietic progenitor cells in their specific stromal microenvironment has been discussed. It appears that membrane lectins on the surface of the stem cell with specificity for galactose with and/or mannose-bearing glycoconjugates on the surface of the stromal cell are involved. This recognition and binding of hemopoietic stem cells which is called “homing” initiates the processes of differentiation, proliferation, and maturation of hemopoietic cells.


Stromal Cell Hemopoietic Stem Cell Hemopoietic Cell Stromal Cell Line Homing Receptor 
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  1. 1.
    Bessis, M. 1977. Erythrocytic series. In: Blood Smears Reinterpreted. M. Bessis, editor. Springer International, Berlin. pp. 25–53.CrossRefGoogle Scholar
  2. 2.
    Westen, H., and D.F. Bainton. 1979. Association of alkaline-phos-phatase-positive reticulum cells in bone marrow with granulocytic precursors. J. Exp. Med. 150: 919–937.PubMedCrossRefGoogle Scholar
  3. 3.
    Ahmad, L.A., and D.F. Bainton. 1986. Presence of alkaline-phosphatase-positive reticulum cells in fetal liver and bone marrow of mice and their absence in yolk sac. Exp. Hematol. 14: 705–709.PubMedGoogle Scholar
  4. 4.
    Tavassoli, M., and M. Aoki. 1981. Migration of entire megakaryocytes through the marrow-blood barriers. Br. J. Hematol. 48: 25–29.CrossRefGoogle Scholar
  5. 5.
    La Pushin, R.W., and J.J. Trentin. 1977. Identification of distinctive stromal elements in erythroid and neutrophil granuloid spleen colonies: light and electron microscopic study. Exp. Hematol. 5: 505–522.PubMedGoogle Scholar
  6. 6.
    Osogoe, B., and K. Omura. 1950. Transplantation of hematopoietic tissue with the circulating blood. Anat. Rec. 108: 663–681.PubMedCrossRefGoogle Scholar
  7. 7.
    Aizawa, S., and M. Tavassoli. 1987. In vitro homing of hemopoietic stem cells is mediated by a recognition system with galactosyl and mannosyl specificities. Proc. Natl. Acad. Sci. USA 84: 4485–4489.PubMedCrossRefGoogle Scholar
  8. 8.
    Aizawa, S., and M. Tavassoli. 1987. In vivo homing of transplanted marrow cells to marrow, but not. spleen, is mediated by lectins with galactosyl and mannosyl specificities. Blood 70: 301a. (Abstract)Google Scholar
  9. 9.
    Aizawa, S., and M. Tavassoli. 1988. Molecular basis of the recognition of intravenously transplanted hemopoietic cells by bone marrow. Proc. Natl. Acad. Sci. USA (In press).Google Scholar
  10. 10.
    Samlowski, W.E., and R.A. Daynes. 1985. Bone marrow engraftment efficiency is enhanced by competitive inhibition of the hepatic asialoglycoprotein receptor. Proc. Natl. Acad. Sci. 82: 2508–2512.PubMedCrossRefGoogle Scholar
  11. 11.
    Reisner, Y., L. Itzicovitch, A. Meshorer, and N. Sharon. 1978. Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins. Proc. Natl. Acad. Sci. 75: 2933–2936.PubMedCrossRefGoogle Scholar
  12. 12.
    Schaaf-La Fontaine, N., R.J. Hooghe, and F. Vander Plaetse. 1985. Modification of blood-borne arrest properties of lymphoma cells by inhibitors of protein glycosylation suggests the existence of endogenous lectins. Carbohydrates Res. 138: 315–323.CrossRefGoogle Scholar
  13. 13.
    Kataoka, M., and M. Tavassoli. 1984. Synthetic neoglycoproteins: A class of reagents for detection of sugar recognizing substances. J. Histochem. Cytochem. 39: 1091–1098.CrossRefGoogle Scholar
  14. 14.
    Sharon, N., and H. Lis. 1982. Glycoproteins: research booming on long-ignored ubiquitous compounds. Mol. Cell Biochem. 42: 167–187.PubMedCrossRefGoogle Scholar
  15. 15.
    Sharon, N., and H. Lis. 1982. Glycoproteins, In: The proteins, 3rd edition, Vol. 5. H. Neurath and R.L. Hill, editors. Academic Press, New York. pp. 1–144.Google Scholar
  16. 16.
    Sharon, N. 1984. Glycoproteins. In: Trends in Biochemical Sciences. J. Hall, editor. Elsevier Science Publishing B.V., Amsterdam, pp. 198–202.Google Scholar
  17. 17.
    Matsuoka, T., and M. Tavassoli. 1988. Characterization of homing receptors in a cloned multipotential hemopoietic cell line. Clin. Res. 36: 16A. (Abstract)Google Scholar
  18. 18.
    Tavassoli, M. 1979. The marrow-blood barrier. Br. J. Haematol. 41: 297–302.PubMedCrossRefGoogle Scholar
  19. 19.
    Weiss, L., and M. Tavassoli. 1970. Anatomical hazards to the passage of erythrocytes throughout the spleen. Sem. Hematol. 7: 372–380.Google Scholar
  20. 20.
    Gallatin, M., T.P. St. John, M. Siegelman, R. Reichert, E.C. Butcher, and I.L. Weissman. 1986. Lymphocyte homing receptors. Cell 44: 673–680.PubMedCrossRefGoogle Scholar
  21. 21.
    St. John, T., W.M. Gallatin, M. Siegelman, H.T. Smith, V.A. Fried, and I.L. Weissman. 1986. Expression — linked cloning of a putative lymph node homing receptor cDNA: Ubiquitin is the reactive species. Science. 321: 845–849.CrossRefGoogle Scholar
  22. 22.
    Siegelman, M., W.M. Bond, W.M. Gallatin, T. St.John, H.T. Smith, V.A. Fried, and I.L. Weissman. 1986. A putative lymphocyte homing receptor is a ubiquitinated branched-chain glycoprotein: additional cell surface proteins also appear ubiquitinated. Science 231: 823–829.PubMedCrossRefGoogle Scholar
  23. 23.
    Gallatin, W.M., I.L. Weissman, and E.C. Butcher. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304: 30–34.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Cheryl L. Hardy
    • 1
    • 2
  • Mehdi Tavassoli
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Division of Hematology/OncologyVA Medical CenterJacksonUSA

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