Homing of Hemopoietic Stem Cells to Hemopoietic Stroma

  • Cheryl L. Hardy
  • Mehdi Tavassoli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


The existing knowledge of the molecular mechanism that underlies the successful engraftment of hemopoietic progenitor cells in their specific stromal microenvironment has been discussed. It appears that membrane lectins on the surface of the stem cell with specificity for galactose with and/or mannose-bearing glycoconjugates on the surface of the stromal cell are involved. This recognition and binding of hemopoietic stem cells which is called “homing” initiates the processes of differentiation, proliferation, and maturation of hemopoietic cells.


Stromal Cell Hemopoietic Stem Cell Hemopoietic Cell Stromal Cell Line Homing Receptor 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Cheryl L. Hardy
    • 1
    • 2
  • Mehdi Tavassoli
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Division of Hematology/OncologyVA Medical CenterJacksonUSA

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