Evaluation of C-SIS mRNA Expression by Human Megakaryocytic Cells in Normals and Patients with Myeloproliferative Disorders

  • L. Kanz
  • R. Mielke
  • A. A. Fauser
  • G. W. Löhr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


Chronic myelogenous leukemia (CML), polycythemia vera, essential thrombocythemia, primary myelofibrosis (PMF) and acute myelofibrosis (acute megakaryoblastic leukemia) form a group of hematological diseases, called myeloproliferative disorders, with varying patterns of lineage involvement in each disorder. There is laboratory and clinical evidence that bone marrow fibrosis in these diseases is promoted, at least in part, by platelet-derived growth factor (PDGF) (for review s. 1,2). PDGF displays growth promoting activity for stroma cells (for review 8.3–5) an¿ possibly, by indirect action for hemopoietic progenitor cells6–8. Its synthesis has been shown by a number of cells, including megakaryocytes, and the B-chain of PDGF is encoded by the c-sis protooncogene3–5.


Chronic Myelogenous Leukemia Polycythemia Vera Essential Thrombocythemia Myeloproliferative Disorder Bone Marrow Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • L. Kanz
    • 1
  • R. Mielke
    • 1
  • A. A. Fauser
    • 1
  • G. W. Löhr
    • 1
  1. 1.Department of Medicine Division of Hematology-OncologyAlbert-Ludwigs-UniversitätFreiburgWest Germany

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