Serum Antioxidant Activity as a Determinant of Pulmonary Dysfunction in Cigarette Smokers

  • Raymond B. Bridges
  • Stanley R. Rehm
Part of the Basic Life Sciences book series (BLSC, volume 49)


Cigarette smoking is a significant risk factor for the development of chronic obstructive pulmonary disease (COPD), and the primary etiology of COPD in smokers is presumably a pulmonary protease-antiprotease imbalance.1 Oxidants in cigarette smoke2,3 and those generated by activated phagocytes4 have both been shown to inactivate the pulmonary antiproteases. This cross-sectional study examined the effects of smoking on total serum antioxidant activity (AOA), the components of peripheral blood which contributed to this AOA, and the relationships between AOA and smoking history or pulmonary dysfunction.


Chronic Obstructive Pulmonary Disease Smoking History Serum Iron Pulmonary Dysfunction Human Neutrophil Elastase 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Raymond B. Bridges
    • 1
  • Stanley R. Rehm
    • 1
  1. 1.Departments of Oral Biology and MedicineUniversity of Kentucky and VA Medical CentersLexingtonUSA

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