Serum Antioxidant Activity as a Determinant of Pulmonary Dysfunction in Cigarette Smokers
Cigarette smoking is a significant risk factor for the development of chronic obstructive pulmonary disease (COPD), and the primary etiology of COPD in smokers is presumably a pulmonary protease-antiprotease imbalance.1 Oxidants in cigarette smoke2,3 and those generated by activated phagocytes4 have both been shown to inactivate the pulmonary antiproteases. This cross-sectional study examined the effects of smoking on total serum antioxidant activity (AOA), the components of peripheral blood which contributed to this AOA, and the relationships between AOA and smoking history or pulmonary dysfunction.
KeywordsChronic Obstructive Pulmonary Disease Smoking History Serum Iron Pulmonary Dysfunction Human Neutrophil Elastase
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