Inclusion of Antioxidants in Resuscitation Fluids
Hemorrhagic shock is, whenever possible, treated with rapid volume replacement. Such treatment is often initiated by paramedical personnel as soon as possible following blood loss, e.g., at the site of an accident and during transport to an emergency room. The fluids used for this type of volume replacement include crystalloids, i.e., solutions of sodium chloride and other inorganic salts. Other volume expanders include biocompatible polysaccharides, so-called colloids, such as hydroxyethyl starch, dextran and human albumin. A considerable amount of research is aimed at developing resuscitation fluids based on solutions of human and bovine hemoglobin. Such stroma-free hemoglobin solutions are intended to deliver oxygen to critical organs where severe hypoxia may lead to irreversible damage.
KeywordsHemorrhagic Shock Iron Chelator Hydroxyethyl Starch Oxygen Radical Scavenger Paramedical Personnel
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