Inclusion of Antioxidants in Resuscitation Fluids

  • Bo E. Hedlund
Part of the Basic Life Sciences book series (BLSC, volume 49)


Hemorrhagic shock is, whenever possible, treated with rapid volume replacement. Such treatment is often initiated by paramedical personnel as soon as possible following blood loss, e.g., at the site of an accident and during transport to an emergency room. The fluids used for this type of volume replacement include crystalloids, i.e., solutions of sodium chloride and other inorganic salts. Other volume expanders include biocompatible polysaccharides, so-called colloids, such as hydroxyethyl starch, dextran and human albumin. A considerable amount of research is aimed at developing resuscitation fluids based on solutions of human and bovine hemoglobin. Such stroma-free hemoglobin solutions are intended to deliver oxygen to critical organs where severe hypoxia may lead to irreversible damage.


Hemorrhagic Shock Iron Chelator Hydroxyethyl Starch Oxygen Radical Scavenger Paramedical Personnel 
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  1. 1.
    H. Hirasawa, M. Odaka, Y. Tabata, H. Kobayashi, and H. Sato, Tissue blood flow in brain, liver, renal cortex and renal medulla in experimental hemorrhagic shock, Crit Care Med. 5;141 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    A. Mazur, S. Baez, and E. Shorr, The mechanism of release from ferritin as related to its biological properities, J. Biol. Chem. 213:147 (1955).PubMedGoogle Scholar
  3. 3.
    S. Green and A. Mazur, Relation of uric acid metabolism to release of iron from hepatic ferritin, J. Biol. Chem. 219:653 (1957).Google Scholar
  4. 4.
    J.M. McCord, Oxygen-derived free radicals in post-ischemic tissue injury, N. Engl. J. Med. 312:159 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    J. Stocks, J.M.C. Gutteridge, R.J. Sharp, and T.L. Dormandy, Assay using brain homogenate for measuring the antioxidant activity of biological fluids, Clin. Sci. Mol. Med, 47:215 (1974).PubMedGoogle Scholar
  6. 6.
    C.L. Meyers, S.J. Weiss, M.M. Kirsch, B.M. Shepard, and M. Shlafer, Effect of supplementing hypothermic crystalloid cardioplegic solutions with catalase, superoxide dismutase, allopurinol and deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts, J. Thoracic Cardiovasc. Surg. 91:281 (1986).Google Scholar
  7. 7.
    G. Ambrosio, M.L. Weisfeldt, W.E. Jacobus, and J.T. Flaherty, Evidence for a reversible oxygen radical mediated component of reperfusion injury: Reduction by recombinant human superoxide dismutase administered at time of reflow, Circulation 75:282 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    G. Ambrosio, J.L. Zweier, W.E. Jacobus, M.L. Weisfeldt, and J.T. Flaherty, Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury, Circulation 76:906 (1987).PubMedCrossRefGoogle Scholar
  9. 9.
    M.S. Palier, J.R. Hoidal, and T.F. Ferris, Oxygen free radicals in ischemic acute renal failure in the rat, J. Clin. Invest. 74:1156 (1984).CrossRefGoogle Scholar
  10. 10.
    M.S. Palier, Role of iron in ischemic and hemoglobinuric acute renal failure, abstract, Kidney International 31:373 (1986).Google Scholar
  11. 11.
    C.F. Babbs, Role of iron in the genesis of reperfusion injury following successful cardiopulmonary resuscitation: Preliminary data and a biochemical hypothesis, Ann. Emerg. Med. 10:501 (1985).Google Scholar
  12. 12.
    S.D. Kompala, C.F. Babbs, and K.E. Blaho, Effect of deferoxamine on late deaths following CPR in rats, Ann Emerg. Med. 15:405 (1986).PubMedCrossRefGoogle Scholar
  13. 13.
    B.C. White, G.S. Krause, S.D. Aust, and G.E. Eyster, Postischemic tissue injury by iron-mediated free radical lipid peroxidation, Ann. Emerg. Med. 14:804 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Bo E. Hedlund
    • 1
  1. 1.University of MinnesotaMinneapolisUSA

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