Porcine Stress Syndrome, Free Radicals and Vitamin E
Widespread among certain breeds of pigs is an inherited tendency to develop a fatal malignant hyperthermia when subjected to stresses such as transportation and exercise. The malignant hyperthermia response can also be pharmacologically triggered in these pigs, and in predisposed humans, by exposure to halothane anesthesia. Characteristically, prior to the rapid increase in body temperature, the limbs become rigid, and at post-mortem, muscle tissue is severely disrupted. Although abnormalities of calcium transport consistent with an inherent membrane defect have been implicated in the etiology of the syndrome, the initial causative factors which trigger the response are unknown.
KeywordsCreatine Kinase Pyruvate Kinase Malignant Hyperthermia Halothane Anesthesia Pyruvate Kinase Activity
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